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Proteintech
VWF/VWFpp Polyclonal Antibody
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Product Details
11778-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Pig,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
VWF, VWFpp Fusion Protein Ag2386 (1-273 aa encoded by .)
Conjugate
Form
Liquid
Concentration
0.27 mg/mL
Amount
40.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody raised against the N-terminal region of pre-pro-vWF recognizes von Willebrand antigen 2 (75-100 kDa) and pro-vWF (309-320 kDa).
Immunogen sequence: MGAQDEEEG IQDLDGLLVF DKIVEVTLLN LPWYNEETEG QRGEMTAPKS PRAKIRGTLC AEGTRGRSST ARCSLFGSDF VNTFDGSMYS FAGYCSYLLA GGCQKRSFSI IGDFQNGKRV SLSVYLGEFF DIHLFVNGTV TQGDQRVSMP YASKGLYLET EAGYYKLSGE AYGFVARIDG SGNFQVLLSD RYFNKTCGLC GNFNIFAEDD FMTQEGTLTS DPYDFANSWA LSSGEQWCER ASPPSSSCNI SSGEMQKVGV DWPGCTWMVC DFWI (1-273 aa encoded by .)
Target Information
Von Willebrand factor (vWf) is a series of self-aggregated structures, all derived from common glycoprotein subunits, synthesized in endothelial cells and megakaryocytes. The molecular mass of the monomeric vWf unit is 225 kDa. vWf binds to circulating factor VIIIc (antihemophilic factor), hereby stabilizing the latter thus being an important factor in the normal primary haemostasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Coagulation Factor VIII; coagulation factor VIII VWF; Factor VIII related antigen; unnamed protein product; von Willebrand antigen II precursor; von Willebrand Disease (vWD); von Willebrand factor; vWF; vwf {ECO:0000312|EMBL:CAB37852.1}
Gene Aliases: 6820430P06Rik; AI551257; B130011O06Rik; C630030D09; F8VWF; VWD; VWF
UniProt ID: (Human) P04275, (Mouse) Q8CIZ8
Entrez Gene ID: (Human) 7450, (Mouse) 22371, (Rat) 116669
protease binding
integrin binding
extracellular matrix structural constituent
protein binding
collagen binding
immunoglobulin binding
identical protein binding
chaperone binding
glycoprotein binding
protein homodimerization activity
protein N-terminus binding
molecular_function
extracellular matrix protein
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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