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Proteintech
Vimentin Polyclonal Antibody
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Product Details
10366-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Deer,
Human,
Mouse,
Pig,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Vimentin Fusion Protein Ag0489 (1-466 aa encoded by BC000163)
Conjugate
Form
Liquid
Concentration
0.27 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MSTRSVSSS SYRRMFGGPG TASRPSSSRS YVTTSTRTYS LGSALRPSTS RSLYASSPGG VYATRSSAVR LRSSVPGVRL LQDSVDFSLA DAINTEFKNT RTNEKVELQE LNDRFANYID KVRFLEQQNK ILLAELEQLK GQGKSRLGDL YEEEMRELRR QVDQLTNDKA RVEVERDNLA EDIMRLREKL QEEMLQREEA ENTLQSFRQD VDNASLARLD LERKVESLQE EIAFLKKLHE EEIQELQAQI QEQHVQIDVD VSKPDLTAAL RDVRQQYESV AAKNLQEAEE WYKSKFADLS EAANRNNDAL RQAKQESTEY RRQVQSLTCE VDALKGTNES LERQMREMEE NFAVEAANYQ DTIGRLQDEI QNMKEEMARH LREYQDLLNV KMALDIEIAT YRKLLEGEES RISLPLPNFS SLNLRETNLD SLPLVDTHSK RTLLIKTVET RDGQVINETS QHHDDLE (1-466 aa encoded by BC000163)
Target Information
Vimentin is a developmentally regulated intermediate filament protein (IFP) found in cells of mesenchymal origin. It is believed to be involved with the intracellular transport of proteins between the nucleus and plasma membrane. Unlike other IFP proteins, vimentin is expressed, along with desmin, during the early stages of cellular development. During the development process, vimentin is exchanged for new, tissue-specific IFPs. Vimentin has been implicated to be involved in the rate of steroid synthesis via its role as a storage network for steroidogenic cholesterol containing lipid droplets. Vimentin phosphorylation by a protein kinase causes the breakdown of intermediate filaments and activation of an ATP and myosin light chain dependent contractile event. This results in cytoskeletal changes that facilitate the interaction of the lipid droplets within mitochondria, and subsequent transport of cholesterol to the organelles leading to an increase in steroid synthesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: epididymis luminal protein 113; FLJ36605; Hel113; RP11-124N14.1; Vim; VIME; Vimentin
Gene Aliases: CTRCT30; HEL113; VIM
UniProt ID: (Human) P08670, (Mouse) P20152, (Rat) P31000
Entrez Gene ID: (Human) 7431, (Mouse) 22352, (Rat) 81818
glycoprotein binding
double-stranded RNA binding
structural constituent of cytoskeleton
structural constituent of eye lens
protein binding
protein C-terminus binding
identical protein binding
scaffold protein binding
keratin filament binding
structural molecule activity
kinase binding
protein kinase binding
protein phosphatase 2A binding
positive regulation of gene expression
negative regulation of neuron projection development
astrocyte development
intermediate filament-based process
intermediate filament organization
regulation of axonogenesis
Bergmann glial cell differentiation
positive regulation of glial cell proliferation
SMAD protein signal transduction
lens fiber cell development
regulation of Schwann cell migration
movement of cell or subcellular component
viral process
muscle filament sliding
aging
response to radiation
response to zinc ion
response to selenium ion
response to estradiol
response to vitamin D
skeletal muscle tissue regeneration
cellular response to fibroblast growth factor stimulus
fat cell differentiation
decidualization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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