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Vimentin Polyclonal Antibody
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FIGURE: 1 / 10
Vimentin Antibody (BS-0756R) in ICC/IF
U-2 OS cells were stained with Vimentin Polyclonal Antibody, Unconjugated(bs-0756R) at 1:50 in PBS and incubated for two hours at 37°C followed by Goat Anti-Rabbit IgG (H+L) FITC conjugated secondary antibody. DAPI staining of the nucleus was done and then detected.
Product Details
BS-0756R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Human,
Mouse,
Non-human primate,
Pig,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human Vimentin, amino acids 371-466.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Vimentin is a developmentally regulated intermediate filament protein (IFP) found in cells of mesenchymal origin. It is believed to be involved with the intracellular transport of proteins between the nucleus and plasma membrane. Unlike other IFP proteins, vimentin is expressed, along with desmin, during the early stages of cellular development. During the development process, vimentin is exchanged for new, tissue-specific IFPs. Vimentin has been implicated to be involved in the rate of steroid synthesis via its role as a storage network for steroidogenic cholesterol containing lipid droplets. Vimentin phosphorylation by a protein kinase causes the breakdown of intermediate filaments and activation of an ATP and myosin light chain dependent contractile event. This results in cytoskeletal changes that facilitate the interaction of the lipid droplets within mitochondria, and subsequent transport of cholesterol to the organelles leading to an increase in steroid synthesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: epididymis secretory sperm binding protein; FLJ36605; Hel113; intermediate filament protein; RP11-124N14.1; unnamed protein product; VIM; VIME; Vimentin
Gene Aliases: VIM
UniProt ID: (Pig) P02543, (Bovine) P48616, (Human) P08670, (Mouse) P20152, (Rat) P31000
Entrez Gene ID: (Pig) 100522394, (Bovine) 280955, (Human) 7431, (Mouse) 22352, (Rat) 81818
double-stranded RNA binding
structural constituent of cytoskeleton
structural constituent of eye lens
protein domain specific binding
identical protein binding
scaffold protein binding
keratin filament binding
protein binding
RNA binding
binding, bridging
glycoprotein binding
structural molecule activity
protein C-terminus binding
kinase binding
protein kinase binding
protein phosphatase 2A binding
negative regulation of neuron projection development
astrocyte development
positive regulation of collagen biosynthetic process
regulation of mRNA stability
intermediate filament organization
positive regulation of translation
Bergmann glial cell differentiation
SMAD protein signal transduction
lens fiber cell development
cellular response to lipopolysaccharide
cellular response to muramyl dipeptide
cellular response to interferon-gamma
positive regulation of gene expression
intermediate filament-based process
regulation of axonogenesis
positive regulation of glial cell proliferation
regulation of Schwann cell migration
in utero embryonic development
positive regulation of superoxide anion generation
neuron projection development
aging
response to radiation
response to zinc ion
response to selenium ion
response to estradiol
response to vitamin D
skeletal muscle tissue regeneration
cellular response to fibroblast growth factor stimulus
fat cell differentiation
decidualization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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