PA5-27231 targets Vimentin in IF, IHC (P), and WB applications and shows reactivity with Human, mouse, and Rat samples.
The PA5-27231 immunogen is recombinant protein fragment corresponding to a region within amino acids 61 and 426 of Human Vimentin.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
This gene encodes a member of the intermediate filament family. Intermediate filamentents, along with microtubules and actin microfilaments, make up the cytoskeleton. The protein encoded by this gene is responsible for maintaining cell shape, integrity of the cytoplasm, and stabilizing cytoskeletal interactions. It is also involved in the immune response, and controls the transport of low-density lipoprotein (LDL)-derived cholesterol from a lysosome to the site of esterification. It functions as an organizer of a number of critical proteins involved in attachment, migration, and cell signaling. Mutations in this gene causes a dominant, pulverulent cataract.
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Protein Aliases: epididymis luminal protein 113; FLJ36605; VIM; Vimentin
Gene Aliases: CTRCT30; HEL113; VIM