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Vitronectin Polyclonal Antibody

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Vitronectin Antibody in Immunocytochemistry (ICC/IF) — Immunofluorescent analysis of ( -20°C Ethanol ) fixed NIH/3T3 cells using 15833-1-AP (Vitronectin antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

Vitronectin Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human hepatocirrhosis tissue slide using 15833-1-AP (Vitronectin antibody at dilution of 1:50 (under 40x lens).

Vitronectin Antibody in Western Blot (WB) — Human testis tissue were subjected to SDS PAGE followed by western blot with 15833-1-AP (Vitronectin antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

Product Details

15833-1-AP

Applications	Tested Dilution	Publications
Western Blot (WB)	1:1,000-1:6,000	View 6 publications 6 publications
Immunohistochemistry (IHC)	-	View 1 publication 1 publication
Immunohistochemistry (Paraffin) (IHC (P))	1:50-1:500	-
Immunocytochemistry (ICC/IF)	1:50-1:500	View 2 publications 2 publications
Miscellaneous PubMed (Misc)	-	View 1 publication 1 publication

Product Specifications
Species Reactivity	Human, Mouse, Rat
Published species	Human
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	Vitronectin Fusion Protein Ag8443 (126-478 aa encoded by BC005046) View immunogen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.33 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.02% sodium azide
Storage conditions	-20°C

Product Specific Information

Immunogen sequence: EVGASKPEG IDSRPETLHP GRPQPPAEEE LCSGKPFDAF TDLKNGSLFA FRGQYCYELD EKAVRPGYPK LIRDVWGIEG PIDAAFTRIN CQGKTYLFKG SQYWRFEDGV LDPDYPRNIS DGFDGIPDNV DAALALPAHS YSGRERVYFF KGKQYWEYQF QHQPSQEECE GSSLSAVFEH FAMMQRDSWE DIFELLFWGR TSAGTRQPQF ISRDWHGVPG QVDAAMAGRI YISGMAPRPS LAKKQRFRHR NRKGYRSQRG HSRGRNQNSR RPSRAMWLSL FSSEESNLGA NNYDDYRMDW LVPATCEPIQ SVFFFSGDKY YRVNLRTRRV DTVDPPYPRS IAQYWLGCPA PGHL (126-478 aa encoded by B C005046)

Target Information

VTN is a member of the pexin family. This protein is found in serum and tissues and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. The protein is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Priming integrin α5 promotes human dental pulp stem cells odontogenic differentiation due to extracellular matrix deposition and amplified extracellular matrix-receptor activity.

Journal of cellular physiology

Wang H,Ning T,Song C,Luo X,Xu S,Zhang X,Deng Z,Ma D,Wu B

Thu Aug 01 00:00:00 EDT 2019

Priming integrin α5 promotes human dental pulp stem cells odontogenic differentiation due to extracellular matrix deposition and amplified extracellular matrix-receptor activity.

Journal of cellular physiology

Wang H,Ning T,Song C,Luo X,Xu S,Zhang X,Deng Z,Ma D,Wu B

Thu Aug 01 00:00:00 EDT 2019

Induction of migration of periodontal ligament cells by selective regulation of integrin subunits.

Journal of cellular and molecular medicine

Kawamura M,Yamamoto T,Yamashiro K,Kochi S,Yoshihara-Hirata C,Ideguchi H,Aoyagi H,Omori K,Takashiba S

Fri Feb 01 00:00:00 EST 2019

Induction of migration of periodontal ligament cells by selective regulation of integrin subunits.

Journal of cellular and molecular medicine

Kawamura M,Yamamoto T,Yamashiro K,Kochi S,Yoshihara-Hirata C,Ideguchi H,Aoyagi H,Omori K,Takashiba S

Fri Feb 01 00:00:00 EST 2019

Characterization of Initial Cell Adhesion on Charged Polymer Substrates in Serum-Containing and Serum-Free Media.

Langmuir : the ACS journal of surfaces and colloids

Hoshiba T,Yoshikawa C,Sakakibara K

Tue Apr 03 00:00:00 EDT 2018

Molecular Camouflage of Plasmodium falciparum Merozoites by Binding of Host Vitronectin to P47 Fragment of SERA5.

Scientific reports

Tougan T,Edula JR,Takashima E,Morita M,Shinohara M,Shinohara A,Tsuboi T,Horii T

Thu Mar 22 00:00:00 EDT 2018

Molecular Camouflage of Plasmodium falciparum Merozoites by Binding of Host Vitronectin to P47 Fragment of SERA5.

Scientific reports

Tougan T,Edula JR,Takashima E,Morita M,Shinohara M,Shinohara A,Tsuboi T,Horii T

Thu Mar 22 00:00:00 EDT 2018

Surface changes of nanotopography by carbon ion implantation to enhance the biocompatibility of silicone rubber: an in vitro study of the optimum ion fluence and adsorbed protein.

Journal of materials science. Materials in medicine

Li X,Zhou X,Chen Y,Yu S,Chen X,Xia X,Shi X,Zhang Y,Fan D

Fri Sep 15 00:00:00 EDT 2017

Secretomes are a potential source of molecular targets for cancer therapies and indicate that APOE is a candidate biomarker for lung adenocarcinoma metastasis.

Molecular biology reports

Liu Z,Gao Y,Hao F,Lou X,Zhang X,Li Y,Wu D,Xiao T,Yang L,Li Q,Qiu X,Wang E

Sat Nov 01 00:00:00 EDT 2014

SILAC-based quantitative proteomic analysis of secretome between activated and reverted hepatic stellate cells.

Proteomics

Zhang H,Wu P,Chen F,Hao Y,Lao Y,Ren L,Sun L,Sun W,Wei H,Chan DW,Jiang Y,He F

Mon Sep 01 00:00:00 EDT 2014

Bioinformatics

Protein Aliases: complement S-protein; epibolin; S-protein; serum spreading factor; Serum-spreading factor; somatomedin B; Somatomedin-B; V75; Vitronectin; Vitronectin V10 subunit; Vitronectin V65 subunit; VN

Gene Aliases: Aa1018; AI256434; V75; VN; VNT; VTN

UniProt ID: (Human) P04004, (Mouse) P29788

Entrez Gene ID: (Human) 7448, (Rat) 29169, (Mouse) 22370

Function(s)

receptor-mediated endocytosis immune response cell-matrix adhesion positive regulation of cell-substrate adhesion negative regulation of endopeptidase activity positive regulation of smooth muscle cell migration extracellular matrix organization positive regulation of protein binding cell adhesion mediated by integrin endodermal cell differentiation positive regulation of receptor-mediated endocytosis positive regulation of peptidyl-tyrosine phosphorylation smooth muscle cell-matrix adhesion cell adhesion negative regulation of blood coagulation regulation of complement activation positive regulation of vascular endothelial growth factor receptor signaling pathway oligodendrocyte differentiation positive regulation of wound healing protein polymerization liver regeneration

Process(es)

scavenger receptor activity integrin binding protein binding heparin binding polysaccharide binding extracellular matrix binding collagen binding identical protein binding

Vitronectin Polyclonal Antibody

Product Details

15833-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Miscellaneous PubMed (Misc)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Product Specific Information

Target Information

Bioinformatics

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