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|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A 19 amino acid peptide near the center of human WAC|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Immunocytochemistry (ICC)||5 ug/ml|
|Immunofluorescence (IF)||5 ug/ml|
|Immunohistochemistry (IHC)||25 ug/ml|
|Western Blot (WB)||1 ug/mL|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
A suggested positive control is human testis tissue lysate.
PA5-34536 can be used with blocking peptide PEP-1579.
The WW domain containing adaptor with coiled-coil protein (WAC) contains a WW domain that mediates protein-protein interactions and colocalizes with RNA splicing factor SC35. Further studies have indicated that WAC is a functional partner of the RNF20/40 complex that ubiquitinates Histone H2B, and that WAC regulates H2B ubiquitination. WAC targets RNF20/40 to associate with RNA polymerase II complex for H2B ubiquitination at active transcription sites. WAC-dependent transcription is also important for cell-cycle checkpoint activation in response to genotoxic stress.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
PRO1741; WAC, WW domain-containing adapter protein with coiled-coil, Wwp4, BM-016; WW domain-containing adapter protein with coiled-coil; WW domain-containing protein 4
1110067P07Rik; A230035H12Rik; AI256735; AI256776; BM-016; DESSH; KIAA1844; PRO1741; WAC; Wwp4