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Product Details
PA5-65336
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human WAC. Recombinant protein control fragment (Product #RP-106031).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2664601
Product Specific Information
Immunogen sequence: NATVVPQNSSA RSTCSLTPAL AAHFSENLIK HVQGWPADHA EKQASRLREE AHNMGTIHMS EICTELKNLR SLVRVCEIQA TLR
Highest antigen sequence identity to the following orthologs - mouse 89%, rat 88%.
Target Information
The WW domain containing adaptor with coiled-coil protein (WAC) contains a WW domain that mediates protein-protein interactions and colocalizes with RNA splicing factor SC35. Further studies have indicated that WAC is a functional partner of the RNF20/40 complex that ubiquitinates Histone H2B, and that WAC regulates H2B ubiquitination. WAC targets RNF20/40 to associate with RNA polymerase II complex for H2B ubiquitination at active transcription sites. WAC-dependent transcription is also important for cell-cycle checkpoint activation in response to genotoxic stress.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: WW domain-containing adapter protein with coiled-coil
Gene Aliases: BM-016; DESSH; KIAA1844; PRO1741; WAC; Wwp4
UniProt ID: (Human) Q9BTA9
Entrez Gene ID: (Human) 51322
transcription, DNA-templated
cellular response to DNA damage stimulus
histone monoubiquitination
positive regulation of macroautophagy
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
G1 DNA damage checkpoint
positive regulation of transcription, DNA-templated
histone H2B conserved C-terminal lysine ubiquitination
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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