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Bethyl Laboratories
WASP Polyclonal Antibody
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WASP Antibody (A300-581A) in WB
Detection of human WASP by western blot. Samples: Whole cell lysate from Jurkat cells. Antibodies: Affinity purified rabbit anti-WASP antibody (Product # A300-581A) (lot A300-581A-1) used for WB at 0.4 µg/mL. Detection: Chemiluminescence with exposure time of 30 seconds.
Product Details
A300-581A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 400 and the C-terminus (residue 462) of Human Wiskott-Aldrich Syndrome Protein.
Conjugate
Form
Liquid
Concentration
0.20 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.0 to 8.0, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
The Wiskott-Aldrich syndrome family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients. A transcript variant arising as a result of alternative promoter usage, and containing a different 5' UTR sequence, has been described, however, its full-length nature is not known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Actin nucleation-promoting factor WAS; eczema-thrombocytopenia; thrombocytopenia 1 (X-linked); WASp; Wiskott-Aldrich syndrome protein
Gene Aliases: IMD2; SCNX; THC; THC1; WAS; WASP; WASPA
UniProt ID: (Human) P42768
Entrez Gene ID: (Human) 7454
regulation of T cell antigen processing and presentation
protein complex assembly
defense response
immune response
blood coagulation
actin polymerization or depolymerization
epidermis development
endosomal transport
actin filament polymerization
actin filament-based movement
Fc-gamma receptor signaling pathway involved in phagocytosis
T cell activation
regulation of catalytic activity
T cell receptor signaling pathway
negative regulation of cell motility
positive regulation of Arp2/3 complex-mediated actin nucleation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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