Proteintech

WDR1 Polyclonal Antibody

WDR1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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WDR1 Antibody (13676-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human testis using 13676-1-AP (WDR1 antibody) at dilution of 1:100 (under 40x lens).

WDR1 Antibody in Immunoprecipitation (IP)

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Product Details

13676-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 9 publications 9 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

WDR1 Fusion Protein Ag4670 (1-350 aa encoded by BC030541)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.15 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MPYEIKKVF ASLPQVERGV SKIIGGDPKG NNFLYTNGKC VILRNIDDHS RFVNCVRFSP DGNRFATASA DGQIYIYDGK TGEKVCALGG SKAHDGGIYA ISWSPDSTHL LSASGDKTSK IWDVSVNSVV STFPMGSTVL DQQLGCLWQK DHLLSVSLSG YINYLDRNNP SKPLHVIKGH SKSIQCLTVH KNGGKSYIYS GSHDGHINYW DSETGENDSF AGKGHTNQVS RMTVDESGQL ISCSMDDTVR YTSLMLRDYS GQGVVKLDVQ PKCVAVGPGG YAVVVCIGQI VLLKDQRKCF SIDNPGYEPE VVAVHPGGDT VAIGGVDGNV RLYSILGTTL KDEGKLLEAK G (1-350 aa encoded by BC030541)

Target Information

This gene encodes a protein containing 9 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, mostly including a trp-asp at the C-terminal end. WD domains are involved in protein-protein interactions. The encoded protein may help induce the disassembly of actin filaments. Two transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

YAP signaling is involved in WDR1-regulated proliferation and migration of non-small-cell lung cancer cells.

Experimental biology and medicine (Maywood, N.J.)

An R,Wang J,Chen X,Xu R,Hu J,Liu Z,Wei C,Zhang C,Yuan B

Thu Sep 01 00:00:00 UTC 2022

WD Repeat Domain 1 Deficiency Inhibits Neointima Formation in Mice Carotid Artery by Modulation of Smooth Muscle Cell Migration and Proliferation.

Molecules and cells

Hu J,Pi S,Xiong M,Liu Z,Huang X,An R,Zhang T,Yuan B

Mon Aug 31 00:00:00 UTC 2020

Hippocampal Wdr1 Deficit Impairs Learning and Memory by Perturbing F-actin Depolymerization in Mice.

Cerebral cortex (New York, N.Y. : 1991)

Wang J,Kou XL,Chen C,Wang M,Qi C,Wang J,You WY,Hu G,Chen J,Gao J

Fri Sep 13 00:00:00 UTC 2019

Hippocampal Wdr1 Deficit Impairs Learning and Memory by Perturbing F-actin Depolymerization in Mice.

Cerebral cortex (New York, N.Y. : 1991)

Wang J,Kou XL,Chen C,Wang M,Qi C,Wang J,You WY,Hu G,Chen J,Gao J

Fri Sep 13 00:00:00 UTC 2019

Knockout of Wdr1 results in cardiac hypertrophy and impaired cardiac function in adult mouse heart.

Gene

Huang X,Li Z,Hu J,Yang Z,Liu Z,Zhang T,Zhang C,Yuan B

Mon May 20 00:00:00 UTC 2019

WDR1-regulated actin dynamics is required for outflow tract and right ventricle development.

Developmental biology

Hu J,Shi Y,Xia M,Liu Z,Zhang R,Luo H,Zhang T,Yang Z,Yuan B

Fri Jun 15 00:00:00 UTC 2018

WDR1-regulated actin dynamics is required for outflow tract and right ventricle development.

Developmental biology

Hu J,Shi Y,Xia M,Liu Z,Zhang R,Luo H,Zhang T,Yang Z,Yuan B

Fri Jun 15 00:00:00 UTC 2018

WDR1 Promotes Cell Growth and Migration and Contributes to Malignant Phenotypes of Non-small Cell Lung Cancer through ADF/cofilin-mediated Actin Dynamics.

International journal of biological sciences

Yuan B,Zhang R,Hu J,Liu Z,Yang C,Zhang T,Zhang C

Mon Aug 12 00:00:00 UTC 2019

WDR1 Promotes Cell Growth and Migration and Contributes to Malignant Phenotypes of Non-small Cell Lung Cancer through ADF/cofilin-mediated Actin Dynamics.

International journal of biological sciences

Yuan B,Zhang R,Hu J,Liu Z,Yang C,Zhang T,Zhang C

Mon Aug 12 00:00:00 UTC 2019

Trp-Asp (WD) Repeat Domain 1 Is Essential for Mouse Peri-implantation Development and Regulates Cofilin Phosphorylation.

The Journal of biological chemistry

Xiao Y,Ma H,Wan P,Qin D,Wang X,Zhang X,Xiang Y,Liu W,Chen J,Yi Z,Li L

Fri Jan 27 00:00:00 UTC 2017

Trp-Asp (WD) Repeat Domain 1 Is Essential for Mouse Peri-implantation Development and Regulates Cofilin Phosphorylation.

The Journal of biological chemistry

Xiao Y,Ma H,Wan P,Qin D,Wang X,Zhang X,Xiang Y,Liu W,Chen J,Yi Z,Li L

Fri Jan 27 00:00:00 UTC 2017

AIP1-mediated actin disassembly is required for postnatal germ cell migration and spermatogonial stem cell niche establishment.

Cell death & disease

Xu J,Wan P,Wang M,Zhang J,Gao X,Hu B,Han J,Chen L,Sun K,Wu J,Wu X,Huang X,Chen J

Thu Jul 16 00:00:00 UTC 2015

AIP1-mediated actin disassembly is required for postnatal germ cell migration and spermatogonial stem cell niche establishment.

Cell death & disease

Xu J,Wan P,Wang M,Zhang J,Gao X,Hu B,Han J,Chen L,Sun K,Wu J,Wu X,Huang X,Chen J

Thu Jul 16 00:00:00 UTC 2015

A cardiomyocyte-specific Wdr1 knockout demonstrates essential functional roles for actin disassembly during myocardial growth and maintenance in mice.

The American journal of pathology

Yuan B,Wan P,Chu D,Nie J,Cao Y,Luo W,Lu S,Chen J,Yang Z

Tue Jul 01 00:00:00 UTC 2014

A cardiomyocyte-specific Wdr1 knockout demonstrates essential functional roles for actin disassembly during myocardial growth and maintenance in mice.

The American journal of pathology

Yuan B,Wan P,Chu D,Nie J,Cao Y,Luo W,Lu S,Chen J,Yang Z

Tue Jul 01 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: Actin-interacting protein 1; AIP1; epididymis secretory protein Li 52; NORI-1; WD repeat protein 1; WD repeat-containing protein 1; WD40 repeat protein 1

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Gene Aliases: AIP1; D5Wsu185e; HEL-S-52; NORI-1; rede; WDR1

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UniProt ID: (Human) O75083, (Rat) Q5RKI0, (Mouse) O88342

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Entrez Gene ID: (Human) 9948, (Rat) 360950, (Mouse) 22388

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Function(s)

actin filament binding actin binding non-motor actin binding protein

Process(es)

platelet degranulation sensory perception of sound regulation of actin filament depolymerization positive regulation of actin filament depolymerization apical junction assembly maintenance of epithelial cell apical/basal polarity sarcomere organization regulation of oligodendrocyte differentiation regulation of ventricular cardiac muscle cell membrane repolarization actin cytoskeleton organization

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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WDR1 Polyclonal Antibody

WDR1 Antibody (13676-1-AP) in IHC (P)

Product Details

13676-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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