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Immunogen sequence: TGADYIVKIF DRHGQKRSEI NLPGNCVAMD WDKDGDVLAV IAEKSSCIYL WDANTNKTSQ LDNGMRDQMS FLLWSKVGSF LAVGTVKG
Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 93%.
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains six WD repeats, a clathrin heavy-chain repeat, and three transmembrane domains. This gene is conserved from C. elegans to human. It may participate in androgen-regulated signaling mechanisms or in the vesicular trafficking of androgen-regulated secretory processes. Alternatively spliced transcript variants encoding distinct isoforms have been reported but the full-length nature of one of these variants has not been defined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Intraflagellar transport 144 homolog; WD repeat membrane protein PWDMP; WD repeat-containing protein 19
Gene Aliases: ATD5; CED4; DYF-2; IFT144; KIAA1638; NPHP13; ORF26; Oseg6; PWDMP; SRTD5; WDR19
UniProt ID: (Human) Q8NEZ3
Entrez Gene ID: (Human) 57728
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