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WDR24 Antibody (PA5-78598) in WB
Western Blot using WDR24 Polyclonal Antibody (Product # PA5-78598). Various whole cell extracts (40 µg) were separated by 7.5% SDS-PAGE, and the membrane was blotted with WDR24 Polyclonal Antibody (Product # PA5-78598) diluted at 1:1,000. The HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.
Product Details
PA5-78598
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human WDR24. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
4.38 mg/mL
Purification
Protein A
Storage buffer
0.1M tris glycine, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2736793
Product Specific Information
Positive Control: MCF-7, U87-MG
Predicted Reactivity: Mouse (100%), Rat (100%), Zebrafish (87%), Xenopus laevis (90%), Bovine (100%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
WDR24, as a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex. WDR24 is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1. In addition to its role in regulation of the TORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GATOR2 complex protein WDR24; WD repeat-containing protein 24
Gene Aliases: C16orf21; JFP7; WDR24
UniProt ID: (Human) Q96S15
Entrez Gene ID: (Human) 84219
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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