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Product Details
PA5-60629
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human WDR35. Recombinant protein control fragment (Product #RP-99642).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2649570
Product Specific Information
Immunogen sequence: SLPNVGLIQK YSLNCRAYQL SLNCNSSRLA IIDISGVLTF FDLDARVTDS TGQQVVGELL KLERRDVWDM KWAKDNPDLF AMMEKTRMYV FRNLDPEEPI QTSGY
Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 93%.
Target Information
WD40 repeats are a common structural module in eukaryotic proteins, and proteins containing WD40 domains have a wide range of functions, including signal transduction, cell cycle regulation, RNA splicing, and transcription. One such protein, WDR35, also known as CED2, has been shown to be mutated in patients with Sensenbrenner syndrome/cranioectodermal dysplasia (CED), an autosomal-recessive disease that is characterized by craniosynstosis and ectodermal and skeletal abnormalities. WDR35 localizes to cilia and dentrosomes during embryogenesis and human and mouse fibroblasts that lack this gene fail to produce cilia. Mutations in this gene can also cause short-rib polydactyly syndromes due to abnormal ciliogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Intraflagellar transport protein 121 homolog; naofen; WD repeat-containing protein 35
Gene Aliases: CED2; IFT121; IFTA1; KIAA1336; SRTD7; WDR35
UniProt ID: (Human) Q9P2L0
Entrez Gene ID: (Human) 57539
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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