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Invitrogen
WDR39 Polyclonal Antibody
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FIGURE: 1 / 1
WDR39 Antibody (PA5-96650) in WB
Western blot analysis of WDR39 in extracts of various cell lines. Samples were incubated with WDR39 Polyclonal antibody (Product # PA5-96650) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 90s.
Product Details
PA5-96650
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-339 of human CIAO1 (NP_0047951)
Conjugate
Form
Liquid
Concentration
0.68 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MKDSLVLLGR VPAHPDSRCW FLAWNPAGTL LASCGGDRRI RIWGTEGDSW ICKSVLSEGH QRTVRKVAWS PCGNYLASAS FDATTCIWKK NQDDFECVTT LEGHENEVKS VAWAPSGNLL ATCSRDKSVW VWEVDEEDEY ECVSVLNSHT QDVKHVVWHP SQELLASASY DDTVKLYREE EDDWVCCATL EGHESTVWSL AFDPSGQRLA SCSDDRTVRI WRQYLPGNEQ GVACSGSDPS WKCICTLSGF HSRTIYDIAW CQLTGALATA CGDDAIRVFQ EDPNSDPQQP TFSLTAHLHQ AHSQDVNCVA WNPKEPGLLA SCSDDGEVAF WKYQRPEGL; Positive Samples: Jurkat, Mouse kidney, Mouse thymus, Mouse heart, Rat heart
Target Information
WDR39 is a member of the WD40 family of proteins. WDR39 specifically interacts with WT1 both in vitro and in vivo. This interaction results in a decrease in transcriptional activation mediated by WT1. WDR39 does not inhibit binding of WT1 to its consensus nucleotide sequence and does not affect the repression activity of WT1. Thus, WDR39 appears to specifically modulate the transactivation activity of WT1 and may function to regulate the physiological functions of WT1 in cell growth and differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CIAO1; ciao1 {ECO:0000255|HAMAP-Rule:MF_03037}; cytosolic iron-sulfur protein assembly 1; cytosolic iron-sulfur protein assembly 1 homolog; Probable cytosolic iron-sulfur protein assembly protein CIAO1; probable cytosolic iron-sulfur protein assembly protein CIAO1 {ECO:0000255|HAMAP-Rule:MF_03037}; WD repeat domain 39; WD repeat-containing protein 39; WD repeat-containing protein 39 {ECO:0000255|HAMAP-Rule:MF_03037}; WD40 protein Ciao1
Gene Aliases: AW210570; CIA1; CIAO1; WDR39
UniProt ID: (Human) O76071, (Rat) Q5M7T1, (Mouse) Q99KN2
Entrez Gene ID: (Human) 9391, (Rat) 29231, (Mouse) 26371
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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