Immunogen sequence: SIIQCHILND KRHILTKDTN NNVAYWDVLK ACKVEDLGKV DFEDEIKKRF KMVYVPNWFS VDLKTGMLTI TLDESDCFAA WVSAKDAGF
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.
Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 by enhancing the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12 and USP46, respectively. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. In case of infection by Herpesvirus saimiri, may play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. Induces lysosomal vesicle formation via interaction with Herpesvirus saimiri tyrosine kinase-interacting protein (TIP). Subsequently, TIP recruits tyrosine-protein kinase LCK, resulting in down-regulation of T-cell antigen receptor TCR. May play a role in generation of enlarged endosomal vesicles via interaction with TIP. In case of infection by papillomavirus HPV11, promotes the maintenance of the viral genome via its interaction with HPV11 helicase E1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: P80; testicular tissue protein Li 224; UAF1; USP1 associated factor 1; USP1-associated factor 1; WD repeat endosomal protein; WD repeat-containing protein 48
Gene Aliases: KIAA1449; P80; SPG60; UAF1; WDR48
UniProt ID: (Human) Q8TAF3
Entrez Gene ID: (Human) 57599