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OriGene
WDR48 Polyclonal Antibody
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FIGURE: 1 / 2
WDR48 Antibody (TA890061) in WB
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY WDR48(RC205497, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-WDR48 r. Positive lysates LY412261 (100 µg) and LC412261 (20 µg) can be purchased separately from OriGene.
Product Details
TA890061
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein of human WDR48
Conjugate
Form
Liquid
Concentration
1.72 mg/mL
Amount
172 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
WD-repeats are motifs that are found in a variety of proteins and are characterized by a conserved core of 40-60 amino acids, which commonly form a tertiary propeller structure. While proteins that contain WD-repeats participate in a wide range of cellular functions, they are generally involved in regulatory mechanisms involving signal transduction, apoptosis, transcriptional regulation and cell cycle control. WD repeats serve as sites for protein-protein interaction and some seem to mediate the assembly of protein complexes. With eight WD repeats, WDR48 (WD repeat-containing protein 48), also known as USP1-associated factor 1 and p80, is a 677 amino acid protein that functions to regulate deubiquitinating complexes via activation of USP1, USP12 and USP46. WDR48 enhances deubiquitination by increasing catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. WDR48 is ubiquitously expressed and is mainly localized to the cytoplasm. There are five isoforms of WDR48 that are expressed as a result of alternative splicing events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: p80; testicular tissue protein Li 224; unnamed protein product; USP1 associated factor 1; USP1-associated factor 1; WD repeat endosomal protein; WD repeat-containing protein 48
Gene Aliases: 8430408H12Rik; Bun62; KIAA1449; mKIAA1449; P80; RGD1309702; SPG60; UAF1; WDR48
UniProt ID: (Human) Q8TAF3, (Mouse) Q8BH57
Entrez Gene ID: (Human) 57599, (Rat) 363164, (Mouse) 67561
double-strand break repair via homologous recombination
cellular response to DNA damage stimulus
spermatogenesis
single fertilization
male gonad development
protein deubiquitination
multicellular organism growth
skin development
embryonic organ development
skeletal system morphogenesis
homeostasis of number of cells
positive regulation of epithelial cell proliferation
seminiferous tubule development
regulation of protein monoubiquitination
DNA repair
JAK-STAT cascade
positive regulation of JAK-STAT cascade
regulation of macromolecule metabolic process
regulation of primary metabolic process
positive regulation of double-strand break repair via homologous recombination
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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