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A suggested positive control is 293 cell lysate.
PA5-34379 can be used with blocking peptide PEP-1422.
WD repeat domain 5 (WDR5) is a member of the WD repeat protein family, which is involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. WDR5, also known as BIG-3, is expressed in the developing growth plate, accelerates chondrocyte and osteoblast differentiation in vitro, and regulates osteoblast differentiation during embryonic bone development. WDR5 interacts with the pluripotency factor Oct4/POU5F1 and is required for the efficient formation of induced pluripotent stem (iPS) cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: BIG-3; BMP2-induced 3-kb gene protein; cilia and flagella associated protein 89; SWD3; SWD3, Set1c WD40 repeat protein, homolog; WD repeat domain 5; WD repeat-containing protein 5; WDR5
Gene Aliases: BIG-3; BIG3; CFAP89; SWD3; WDR5
UniProt ID: (Human) P61964
Entrez Gene ID: (Human) 11091
Molecular Function:
RNA binding protein
enzyme modulator
esterase
hydrolase
kinase inhibitor
kinase modulator
mRNA processing factor
mRNA splicing factor
nucleic acid binding
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