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Proteintech
WDR59 Polyclonal Antibody
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Product Details
26289-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
WDR59 fusion protein Ag23495
Conjugate
Form
Liquid
Concentration
750 µg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Sequence of this protein is as follows: WKSKREGSDS GNRQIKAAGK VIIQDIACLL PVHKSLGELY ILNVNDIQET CQKNAASALL VGRKDLVQVW SLATVATDLC LGPKSDPDLE TPWARHPFGR QLLESLLAHY CRLRDVQTLA MLCSVFEAQS RPQGLPNPFG PFPNRSSNLV VSHSRYPSFT SSGSCSSMSD PGLNTGGWNI AGREAEHLSS PWGESSPEEL RFGSLTYSDP RERERDQHDK NKRLLDPANT QQFDDFKKCY GEILYRWGLR EKRAEVLKFV SCPPDPHKGI EFGVYCSHCR SEVRGTQCAI CKGFTFQCAI CHVAVRGSSN FCLTCGHGGH TSHMMEWFRT QEVCPTGCGC HCLLESTF
Target Information
As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:25457612, PubMed:27487210). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CUL4- and DDB1-associated WDR protein 12; GATOR2 complex protein WDR59; WD repeat-containing protein 59
Gene Aliases: 5430401O09Rik; Cdw12; FP977; KIAA1923; WDR59
UniProt ID: (Human) Q9HA43, (Mouse) Q8C0M0
Entrez Gene ID: (Human) 79726, (Mouse) 319481
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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