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Product Details
22536-1-AP
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
WDR61 Fusion Protein Ag18443 (1-305 aa encoded by BC010080) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.36 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Product Specific Information
Product # 22536-1-AP is a rabbit polyclonal antibody raised against the full-length of human WDR61. The MW of this protein is 33 kDa, and this antibody specifically recognizes the 33 kDa protein.
Immunogen sequence: MTNQYGILF KQEQAHDDAI WSVAWGTNKK ENSETVVTGS LDDLVKVWKW RDERLDLQWS LEGHQLGVVS VDISHTLPIA ASSSLDAHIR LWDLENGKQI KSIDAGPVDA WTLAFSPDSQ YLATGTHVGK VNIFGVESGK KEYSLDTRGK FILSIAYSPD GKYLASGAID GIINIFDIAT GKLLHTLEGH AMPIRSLTFS PDSQLLVTAS DDGYIKIYDV QHANLAGTLS GHASWVLNVA FCPDDTHFVS SSSDKSVKVW DVGTRTCVHT FFDHQDQVWG VKYNGNGSKI VSVGDDQEIH IYDCPI (1-305 aa encoded by B C010080)
Target Information
SKI8 is a component of the PAF and SKI complex which is composed of SKI2, SKI3 and SKI8. These are involved in transcriptional regulation and events downstream of RNA synthesis. Interaction of the SKI complex with SKI7 links the SKI complex to the exosome in order to perform mRNA degradation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: meiotic recombination protein REC14; Meiotic recombination REC14 protein homolog; recombination protein REC14; Ski8; SKI8 homolog; WD repeat-containing protein 61; WD repeat-containing protein 61, N-terminally processed
Gene Aliases: 2700038L12Rik; 2810418I05Rik; REC14; RGD1308228; SKI8; WDR61
UniProt ID: (Human) Q9GZS3, (Rat) Q4V7A0, (Mouse) Q9ERF3
Entrez Gene ID: (Human) 80349, (Rat) 363064, (Mouse) 66317
transcription, DNA-templated
Wnt signaling pathway
positive regulation of transcription elongation from RNA polymerase II promoter
negative regulation of myeloid cell differentiation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of histone H3-K4 methylation
histone H3-K4 trimethylation
positive regulation of histone H3-K79 methylation
regulation of transcription, DNA-templated
positive regulation of histone methylation
nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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