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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 93 and 342 of Human WDR77|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 20% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:5000-1:20,000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-30811 targets WDR77 in IF, IHC (P), and WB applications and shows reactivity with Human samples.
The PA5-30811 immunogen is recombinant fragment corresponding to a region within amino acids 93 and 342 of Human WDR77.
WDR77 is a component of the 20S PRMT5 (MIM 604045)-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins (see MIM 601061). This modification targets Sm proteins to the survival of motor neurons (SMN) complex (see MIM 600354) for assembly into small nuclear ribonucleoprotein core particles (Friesen et al., 2002 [PubMed 11756452]).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
androgen receptor cofactor p44; MEP50; methylosome protein 50; Nbla10071; RP11-552M11.3; testis tissue sperm-binding protein Li 44a; WD repeat-containing protein 77
HKMT1069; MEP-50; MEP50; Nbla10071; p44; p44/Mep50; WD45; WDR77