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Bethyl Laboratories
WDR77/MEP50 Polyclonal Antibody
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FIGURE: 1 / 3
WDR77/MEP50 Antibody (IHC-00338) in IHC (P)
Detection of human WDR77/MEP50 by IHC-IF. Sample: FFPE section of human prostate carcinoma. Antibody: Affinity purified rabbit anti-WDR77/MEP50 (Product # IHC-00338) used at a dilution of 1:100. Detection: Red-fluorescent goat anti-rabbit IgG highly cross-adsorbed Antibody Hilyte Plus™ 555 used at a dilution of 1:100.
Product Details
IHC-00338
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 292 and 342 of Human WD repeat domain 77 (methylosome protein 50).
Conjugate
Form
Liquid
Concentration
50 µg/mL
Amount
5 µg
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.0 to 8.0, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Orangutan, Monkey, Chimpanzee and Northern white-cheeked gibbon
Target Information
WDR77 is a component of the 20S PRMT5-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Androgen receptor cofactor p44; MEP-50; Methylosome protein 50; Methylosome protein WDR77; MGC2722; OTTHUMP00000013473; p44/Mep50; RP11-552M11.3; testis tissue sperm-binding protein Li 44a; unnamed protein product; WD repeat-containing protein 77
Gene Aliases: 2610003I18Rik; 2610312E17Rik; C79984; HKMT1069; MEP-50; MEP50; Nbla10071; p44; p44/MEP50; WD45; WDR77
UniProt ID: (Human) Q9BQA1, (Mouse) Q99J09
Entrez Gene ID: (Human) 79084, (Mouse) 70465
protein polyubiquitination
spliceosomal snRNP assembly
regulation of transcription from RNA polymerase II promoter
ubiquitin-dependent protein catabolic process
oocyte axis specification
positive regulation of cell proliferation
negative regulation of cell proliferation
positive regulation of transcription, DNA-templated
positive regulation of mRNA splicing, via spliceosome
secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
epithelial cell proliferation involved in prostate gland development
negative regulation of epithelial cell proliferation involved in prostate gland development
regulation of nucleic acid-templated transcription
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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