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Proteintech
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Immunogen sequence: TEFHELEKI GSGEFGSVFK CVKRLDGCIY AIKRSKKPLA GSVDEQNALR EVYAHAVLGQ HSHVVRYFSA WAEDDHMLIQ NEYRNGGSLA DAISENYRIM SYFKEAELKD LLLQVGRGLR YIHSMSLVHM DIKPSNIFIS RTSIPNAASE EGDEDDWASN KVMFKIGDLG HVTRISSPQV EEGDSRFLAN EVLQENYTHL PKADIFALAL TVVCAAGAEP LPRNGDQWHE IRQGRLPRIP QVLSQEFTEL LKVMIHPDPE RRPSAMALVK HSVLLSASRK SAEQLRIELN AEKFKNSLLQ KELKKAQMAK AAAEERALFT DRMATRSTTQ SNRTSRLIGK KMNRSVSLTI Y (297-646 aa encoded by BC051831)
WEE1, which is classified as a Ser/Thr kinase by sequence analysis, has been shown to inactivate multiple CDKs by tyrosine phosphorylation. Wee1 protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase.
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