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Immunogen sequence: LLCPSGYECH ILSPGDVAEG IPNRGQCVKQ RRQADGRILR HKLYKEYPEG DSKNVAEPGR GQQKHFQ
Highest antigen sequence identity to the following orthologs: Mouse - 82%, Rat - 81%.
This gene encodes a member of the WAP-type four disulfide core domain family. The WAP-type four-disulfide core domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. The encoded protein shares 81% amino acid identity with the rat ps20 protein, which was originally identified as a secreted growth inhibitor. This gene is mapped to chromosome 16q24, an area of frequent loss of heterozygosity in cancers, including prostate, breast and hepatocellular cancers and Wilms' tumor. Owing to its location and a possible growth inhibitory property of its gene product, this gene is suggested to be a tumor suppressor gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Prostate stromal protein ps20; ps20 growth inhibitor; WAP four-disulfide core domain 1 homolog; WAP four-disulfide core domain protein 1
Gene Aliases: PS20; WFDC1
UniProt ID: (Human) Q8NC27
Entrez Gene ID: (Human) 58189
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