This gene encodes a member of the WAP-type four-disulfide core (WFDC) domain family. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. The encoded protein contains four WFDC domains. Most WFDC genes are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the telomeric cluster. Alternatively spliced transcript variants have been observed but their full-length nature has not been determined.
Protein Aliases: protease inhibitor WAP14; Putative protease inhibitor WAP14; WAP four-disulfide core domain protein 3; whey acidic protein 14
Gene Aliases: dJ447F3.3; WAP14; WFDC3
UniProt ID: (Human) Q8IUB2
Entrez Gene ID: (Human) 140686
Molecular Function: protease inhibitor