Immunogen sequence: MQRPSLPDLS RPNTTSSTGM KHSSSAPPPP PPGRRANAPP TPLPMHSSKA PAYNREKPLP PTPGQRLHPG REGPPAPP
Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 92%.
This gene belongs to the GPI family whose members encode multifunctional phosphoglucose isomerase proteins involved in energy pathways. The protein encoded by this gene is a dimeric enzyme that catalyzes the reversible isomerization of glucose-6-phosphate and fructose-6-phosphate. The protein functions in different capacities inside and outside the cell. In the cytoplasm, the gene product is involved in glycolysis and gluconeogenesis, while outside the cell it functions as a neurotrophic factor for spinal and sensory neurons. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: WAS/WASL interacting protein family, member 2; WAS/WASL-interacting protein family member 2; WASP-binding protein; WASP-interacting protein-related protein; WICH; WIP- and CR16-homologous protein; WIP-related protein; WIRE
Gene Aliases: PP10631; WICH; WIPF2; WIRE
UniProt ID: (Human) Q8TF74
Entrez Gene ID: (Human) 147179