This Antibody was verified by KnockDown to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: ECALMKQHRL DGSLETTNEI LDSASHDCPL VTQTYGAAAG KGTYVPSSPT RLAYTDDLGA VGGACLEDEA SALRLDEDSE HPPMILRTD
Highest antigen sequence identity to the following orthologs: Mouse - 83%, Rat - 84%.
WD repeat proteins play a role in many essential biologic functions, regulating the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. WIPI2, also known as ATG18B or ATG21, is a human homolog to yeast ATG18 and contains three WD repeats and has a 7-bladed propeller structure with a conserved motif that facilitates its interaction with other proteins. It is recruited to early autophagosomal structures along with Atg16L and ULK1 and is required for the formation of LC3-positive autophagosomes. Along with the highly related WIPI1, WIPI2 is found at the plasma membrane in addition to autophagosomal membranes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ATG18B; ATG21; CGI-50; WD repeat domain phosphoinositide interacting 2; WD repeat domain phosphoinositide-interacting protein 2; WD40 repeat protein interacting with phosphoinositides 2; WIPI-2; WIPI2; WIPI49-like protein 2
Gene Aliases: 1110018O08Rik; 2510001I10Rik; ATG18B; Atg21; CGI-50; WIPI-2; WIPI2