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Invitrogen

WNK1 Polyclonal Antibody

View all (19) WNK1 antibodies

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Product Details

PA5-33111

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

7 µg/mL
-
Product Specifications

Species Reactivity

Human, Non-human primate

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic 19 amino acid peptide from internal region of human WNK1.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.1% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2550570

Product Specific Information

Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset (100%); Elephant, Panda (95%); Bat, Rabbit, Pig (89%); Mouse, Rat, Hamster (84%).

For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

Target Information

WNK1 serine/threonine kinase is a member of the WNK subfamily. WNK1 may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. WNK plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Also, acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, and SGK1. WNK localizes to a segment of kidney involved in salt, potassium, and pH homeostasis, the distal nephron. Mutations in the WNK gene result in Pseudohypaldosteronism and Neuropathy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Erythrocyte 65 kDa protein; hWNK1; KIAA0344; Kinase deficient protein; MGC163339; MGC163341; p65; prostate-derived sterile 20-like kinase; Protein kinase lysine-deficient 1; Protein kinase with no lysine 1; protein phosphatase 1, regulatory subunit 167; Serine/threonine-protein kinase WNK1; serine/threonine-protein kinase WNK1 1; serine/threonine-protein kinase WNK1 2; With no K

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Gene Aliases: HSAN2; HSN2; KDP; KIAA0344; p65; PPP1R167; PRKWNK1; PSK; WNK1

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UniProt ID: (Human) Q9H4A3

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Entrez Gene ID: (Human) 65125

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Function(s)
nucleotide binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding kinase activity transferase activity protein kinase binding phosphatase binding protein kinase activator activity protein serine kinase activity molecular condensate scaffold activity
Process(es)
regulation of sodium ion transport positive regulation of systemic arterial blood pressure protein phosphorylation ion transport cell volume homeostasis cellular response to DNA damage stimulus signal transduction heart development regulation of blood pressure negative regulation of autophagy negative regulation of sodium ion transport regulation of mRNA export from nucleus positive regulation of T cell chemotaxis cellular chloride ion homeostasis negative regulation of protein ubiquitination negative regulation of cell-cell adhesion mediated by integrin negative regulation of heterotypic cell-cell adhesion intracellular signal transduction sodium ion transmembrane transport chemokine (C-C motif) ligand 21 signaling pathway homeostatic process protein insertion into ER membrane by stop-transfer membrane-anchor sequence positive regulation of angiogenesis neuron development T cell receptor signaling pathway negative regulation of small GTPase mediated signal transduction potassium ion homeostasis cation homeostasis cellular hyperosmotic response potassium ion transmembrane transport negative regulation of pancreatic juice secretion positive regulation of canonical Wnt signaling pathway lymphocyte migration into lymph node membraneless organelle assembly regulation of sodium ion transmembrane transport negative regulation of leukocyte cell-cell adhesion negative regulation of protein localization to plasma membrane positive regulation of mitotic cytokinesis regulation of cation transmembrane transport positive regulation of termination of RNA polymerase II transcription cellular response to chemokine
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