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Invitrogen

WNK1 Polyclonal Antibody

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WNK1 Polyclonal Antibody

Product Details

PA5-80229

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-0.5 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

0.5-1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of human WNK1 (1154-1195aa DNPEEIATIMVNNDFILAIERESFVDQVREIIEKADEMLSED).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

500 µg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS with 5mg BSA

Contains

0.05mg sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2747343

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Positive Control - WB: rat testis tissue. IHC: mouse testis tissue, rat testis tissue, human intestinal cancer tissue.

Target Information

WNK1 serine/threonine kinase is a member of the WNK subfamily. WNK1 may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. WNK plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Also, acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, and SGK1. WNK localizes to a segment of kidney involved in salt, potassium, and pH homeostasis, the distal nephron. Mutations in the WNK gene result in Pseudohypaldosteronism and Neuropathy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Erythrocyte 65 kDa protein; hWNK1; KIAA0344; Kinase deficient protein; MGC163339; MGC163341; p65; prostate-derived sterile 20-like kinase; Protein kinase lysine-deficient 1; Protein kinase with no lysine 1; protein phosphatase 1, regulatory subunit 167; Serine/threonine-protein kinase WNK1; serine/threonine-protein kinase WNK1 1; serine/threonine-protein kinase WNK1 2; With no K

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Gene Aliases: 6430573H23Rik; EG406236; HSAN2; HSN2; KDP; KIAA0344; mKIAA0344; p65; PPP1R167; PRKWNK1; PSK; WNK1

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UniProt ID: (Human) Q9H4A3, (Rat) Q9JIH7, (Mouse) P83741

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Entrez Gene ID: (Human) 65125, (Rat) 116477, (Mouse) 232341

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Function(s)
nucleotide binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding kinase activity transferase activity protein kinase binding phosphatase binding protein kinase activator activity protein serine kinase activity molecular condensate scaffold activity magnesium ion binding chloride channel inhibitor activity potassium channel inhibitor activity protein serine/threonine kinase inhibitor activity protein kinase inhibitor activity transferase activity, transferring phosphorus-containing groups non-receptor serine/threonine protein kinase
Process(es)
regulation of sodium ion transport positive regulation of systemic arterial blood pressure protein phosphorylation ion transport cell volume homeostasis cellular response to DNA damage stimulus signal transduction heart development regulation of blood pressure negative regulation of autophagy negative regulation of sodium ion transport regulation of mRNA export from nucleus positive regulation of T cell chemotaxis cellular chloride ion homeostasis negative regulation of protein ubiquitination negative regulation of cell-cell adhesion mediated by integrin negative regulation of heterotypic cell-cell adhesion intracellular signal transduction sodium ion transmembrane transport chemokine (C-C motif) ligand 21 signaling pathway homeostatic process protein insertion into ER membrane by stop-transfer membrane-anchor sequence positive regulation of angiogenesis neuron development T cell receptor signaling pathway negative regulation of small GTPase mediated signal transduction potassium ion homeostasis cation homeostasis cellular hyperosmotic response potassium ion transmembrane transport negative regulation of pancreatic juice secretion positive regulation of canonical Wnt signaling pathway lymphocyte migration into lymph node membraneless organelle assembly regulation of sodium ion transmembrane transport negative regulation of leukocyte cell-cell adhesion negative regulation of protein localization to plasma membrane positive regulation of mitotic cytokinesis regulation of cation transmembrane transport positive regulation of termination of RNA polymerase II transcription cellular response to chemokine negative regulation of phosphatase activity negative regulation of kinase activity protein autophosphorylation regulation of cellular process negative regulation of protein serine/threonine kinase activity phosphorylation
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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