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Bethyl Laboratories
WNK3 Polyclonal Antibody
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FIGURE: 1 / 1
WNK3 Antibody (A301-877A) in WB
Detection of human WNK3 by western blot and immunoprecipitation. Samples: Whole cell lysate from HeLa (5, 15 and 50 µg for WB; 1 mg for IP, 20% of IP loaded) and HEK293T (T; 50 µg) cells. Antibodies: Affinity purified rabbit anti-WNK3 antibody (Product # A301-877A) used for WB at 0.04 µg/mL (A) and 0.1 µg/mL (B) and used for IP at 3 µg/mg lysate. Detection: Chemiluminescence with exposure times of 10 seconds (A and B).
Product Details
A301-877A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 1 and 50 of Human WNK lysine deficient protein kinase 3.
Conjugate
Form
Liquid
Concentration
0.20 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.0 to 8.0, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
WNK3 is a serine/threonine kinase involved in signal transduction and cellular communication. Members of the 'with no lysine' kinase family, such as WNK3, are serine-threonine protein kinases that lack the almost invariant catalytic lysine in subdomain II, which is important for binding ATP in the catalytic site. Instead, these kinases have a conserved lysine in subdomain I that is thought to provide this function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Prieto X-linked mental retardation syndrome; PRKWNK 3; Protein kinase lysine-deficient 3; Protein kinase with no lysine 3; Serine/threonine-protein kinase WNK3; WNK 3
Gene Aliases: KIAA1566; MRXS2; PRKWNK3; PRS; WNK3
UniProt ID: (Human) Q9BYP7
Entrez Gene ID: (Human) 65267
protein phosphorylation
cell volume homeostasis
cellular response to DNA damage stimulus
osmosensory signaling pathway
positive regulation of sodium ion transport
positive regulation of peptidyl-threonine phosphorylation
intracellular signal transduction
maintenance of blood-brain barrier
negative regulation of apoptotic process
ion homeostasis
positive regulation of calcium ion transport
renal sodium ion absorption
cellular hyperosmotic response
protein localization to plasma membrane
negative regulation of pancreatic juice secretion
regulation of calcium ion import
membraneless organelle assembly
negative regulation of protein localization to plasma membrane
positive regulation of protein localization to plasma membrane
regulation of cation transmembrane transport
positive regulation of sodium ion transmembrane transporter activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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