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Invitrogen
WNK3 Polyclonal Antibody
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FIGURE: 1 / 4
WNK3 Antibody (PA5-96362) in IHC (P)
Immunohistochemistry analysis of WNK3 in paraffin-embedded human liver cancer. Samples were incubated with WNK3 Polyclonal antibody (Product # PA5-96362) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
PA5-96362
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein of rat WNK3.
Conjugate
Form
Liquid
Concentration
0.98 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: Rat hypothalamus, Rat CNS, Rat brain; Cellular Location: Cytoplasm
Target Information
WNK3 is a serine/threonine kinase involved in signal transduction and cellular communication. Members of the 'with no lysine' kinase family, such as WNK3, are serine-threonine protein kinases that lack the almost invariant catalytic lysine in subdomain II, which is important for binding ATP in the catalytic site. Instead, these kinases have a conserved lysine in subdomain I that is thought to provide this function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Prieto X-linked mental retardation syndrome; PRKWNK 3; Protein kinase lysine-deficient 3; Protein kinase with no lysine 3; Serine/threonine-protein kinase WNK3; WNK 3; WNK lysine deficient protein kinase 3, pseudogene
Gene Aliases: KIAA1566; MRXS2; PRKWNK3; PRS; RGD1563131; WNK3; Wnk3-ps
UniProt ID: (Human) Q9BYP7, (Mouse) Q80XP9
Entrez Gene ID: (Human) 65267, (Mouse) 279561, (Rat) 317420
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
ion channel binding
protein serine kinase activity
molecular condensate scaffold activity
transporter activator activity
transferase activity, transferring phosphorus-containing groups
chloride channel inhibitor activity
non-receptor serine/threonine protein kinase
protein phosphorylation
cell volume homeostasis
cellular response to DNA damage stimulus
osmosensory signaling pathway
positive regulation of sodium ion transport
positive regulation of peptidyl-threonine phosphorylation
intracellular signal transduction
maintenance of blood-brain barrier
negative regulation of apoptotic process
ion homeostasis
positive regulation of calcium ion transport
renal sodium ion absorption
cellular hyperosmotic response
protein localization to plasma membrane
negative regulation of pancreatic juice secretion
regulation of calcium ion import
membraneless organelle assembly
negative regulation of protein localization to plasma membrane
positive regulation of protein localization to plasma membrane
regulation of cation transmembrane transport
positive regulation of sodium ion transmembrane transporter activity
phosphorylation
positive regulation of ion transmembrane transporter activity
protein autophosphorylation
positive regulation of establishment of protein localization to plasma membrane
regulation of ion homeostasis
positive regulation of rubidium ion transport
positive regulation of rubidium ion transmembrane transporter activity
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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