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Product Details
PA5-53437
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human WNK4
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2649659
Product Specific Information
Immunogen sequence: ISEEGKPQLV GRFQVTSSKE PAEPLPLQPT SPTLSGSPKP STPQLTSESS DTEDSAGGGP ETREALAESD RAAEGLGAGV EEEGDDGKEP QVGGSPQPLS HPSPVWMNYS YSSLCLSSEE SESSGEDEEF WAEL
Highest antigen sequence identity to the following orthologs: Mouse - 85%, Rat - 87%.
Target Information
This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Protein kinase lysine-deficient 4; Protein kinase with no lysine 4; RP23-281C18.8; Serine/threonine-protein kinase WNK4
Gene Aliases: PHA2B; PRKWNK4; WNK4
UniProt ID: (Human) Q96J92
Entrez Gene ID: (Human) 65266
protein phosphorylation
ion transport
chloride transport
protein localization
positive regulation of ion transmembrane transporter activity
intracellular signal transduction
regulation of cellular process
ion homeostasis
renal sodium ion absorption
distal tubule morphogenesis
negative regulation of pancreatic juice secretion
regulation of ion homeostasis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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