The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is strongly expressed in the cell lines of promyelocytic leukemia and Burkitt's lymphoma. In addition, it and another family member, the WNT6 gene, are strongly coexpressed in colorectal cancer cell lines. The gene overexpression may play key roles in carcinogenesis through activation of the WNT-beta-catenin-TCF signaling pathway. This gene and the WNT6 gene are clustered in the chromosome 2q35 region.
Protein Aliases: Protein Wnt-10a; wingless related MMTV integration site 10a; wingless-type MMTV integration site family member 10A; wingless-type MMTV integration site family, member 10A
Gene Aliases: OODD; SSPS; STHAG4; WNT10A
Molecular Function: signaling molecule