Peptide sequence: MAPLGYFLLL CSLKQALGSY PIWWSLAVGP QYSSLGSQPI LCASIPGLVP
Sequence homology: Cow: 79%; Dog: 79%; Guinea Pig: 79%; Horse: 93%; Human: 100%; Mouse: 86%; Pig: 93%; Rabbit: 79%; Rat: 86%; Zebrafish: 79%
The Wnt gene family encodes secreted signaling molecules that bind to frizzled receptors and influence oncogenesis and developmental processes, including regulation of cell fate and patterning during embryogenesis. The Wnt family has two functional classes according to their biological activities; Wnts that signal through a Wnt-1/wingless pathway by stabilizing cytoplasmic beta-catenin, and Wnts that stimulate intracellular Ca2+ release and activate two kinases, CamKII and PKC, in a G protein-dependent manner. Wnt-3a is an intercellular signaling molecule that mediates cytoskeletal reorganization and regulates hippocampal development. Human Wnt-3a is 96% homologous to mouse Wnt-3a protein and 84% homologous to human Wnt-3 protein. The human Wnt-3a gene clusters with the Wnt-14 gene at chromosome 1q42.
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Protein Aliases: MGC119418; MGC119419; MGC119420; Protein Wnt-3a; vestigial tail; wingless-related MMTV integration site 3A; Wingless-type MMTV integration site family member 3A; wingless-type MMTV integration site family, member 3 like; wingless-type MMTV integration site family, member 3A; wnt3 like
Gene Aliases: vt; Wnt-3a; wnt3; wnt3 l; WNT3A; wnt3l; wnt[a]; Zwnt[a]
Molecular Function: signaling molecule