Immunogen sequence: FAVTRACSSG ELEKCGCDRT VHGVSPQGFQ WSGCSDNIAY GVAFSQSFVD VRERSKGASS SRALMNLHNN EAGRKAILTH MRVECKCHGV SGSCEVKTCW RAVPPFRQVG HALKEKFDGA TEVEPRRVGS SRALVPRNAQ FKPHTDEDLV YLEPSPDFCE QDMRSGVLGT RGRTCNKTSK AIDGCELLCC GRGFHTAQVE LAERCSCKFH WCCFVKCRQC QRLVELHTCR; Positive Samples: A-549, MCF7; Cellular Location: extracellular matrix, extracellular space
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions as a half-transporter to limit intestinal absorption and promote biliary excretion of sterols. It is expressed in a tissue-specific manner in the liver, colon, and intestine. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG8. Mutations in this gene may contribute to sterol accumulation and atherosclerosis, and have been observed in patients with sitosterolemia.
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Protein Aliases: Protein Wnt-4; signal molecule; wingless-related MMTV integration site 4; wingless-type MMTV integration site family member 4; wingless-type MMTV integration site family, member 4
Gene Aliases: SERKAL; UNQ426/PRO864; WNT-4; WNT4
Molecular Function: signaling molecule