Immunogen sequence: GSLSEEEANG PELGSGKAME DTSGEPAAED EGDTAWNYSF SQLPRFLSGS WSEFSTQPEN FLKGCKWAPD GSCILTNSAD NILRIYNLPP ELYHEGEQVE YAEMVPVLRM VEGDTIYDYC
Highest antigen sequence identity to the following orthologs: Mouse - 80%, Rat - 81%.
This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs.
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Protein Aliases: TCAB1; Telomerase Cajal body protein 1; WD repeat containing, antisense to TP53; WD repeat-containing protein 79; WD repeat-containing protein WRAP53; WD40 protein Wrap53; WD40 repeat-containing protein antisense to TP53; WD40 repeat-containing protein antisense to TP53 gene; WD40 repeat-containing protein encoding RNA antisense to p53; WDR79; WRAP53beta
Gene Aliases: DKCB3; TCAB1; WDR79; WRAP53
UniProt ID: (Human) Q9BUR4
Entrez Gene ID: (Human) 55135