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Invitrogen
WRN Polyclonal Antibody
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FIGURE: 1 / 1
WRN Antibody (PA5-19476) in WB
Western blot analysis of Mouse Heart Tissue Lysate using Product # PA5-19476, Werner's syndrome helicase WRN primary antibody at a dilution of 1 µg/mL. Blot treated with a secondary HRP-conjugated Goat polyclonal anti-Rabbit antibody was used at a dilution of 1:3000.
Product Details
PA5-19476
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide conjugated to KLH derived from within residues 350 - 450 of Mouse Werner's syndrome helicase WRN.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
Product Specific Information
PA5-19476 targets Werner's syndrome helicase WRN in WB applications and shows reactivity with mouse samples.
The PA5-19476 immunogen is synthetic peptide conjugated to KLH derived from within residues 350 - 450 of Mouse Werner's syndrome helicase WRN.
PA5-19476 detects Werner's syndrome helicase WRN which has a predicted molecular weight of approximately 150 kDa.
Target Information
This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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