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Invitrogen
WRN Polyclonal Antibody
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Product Details
PA5-83025
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human WRN. Recombinant protein control fragment (Product #RP-89491).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: KADIRQVIHY GAPKDMESYY QEIGRAGRDG LQSSCHVLWA PADINLNRHL LTEIRNEKFR LYKLKMMAKM EKYLHSSRCR RQIILSHFED KQVQKASLGI MGTEKCCDNC RSRLDHCYSM DDSEDTSWDF GPQAFKLLSA VD
Highest antigen sequence indentity to the following orthologs: Rat - 82%, Mouse - 82%.
Target Information
This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN; DKFZp686C2056; DNA helicase, RecQ-like type 3; exonuclease WRN; RecQ protein-like 2; Werner syndrome protein; Werner syndrome, RecQ helicase-like
Gene Aliases: RECQ3; RECQL2; RECQL3; WRN
UniProt ID: (Human) Q14191
Entrez Gene ID: (Human) 7486
magnesium ion binding
Y-form DNA binding
bubble DNA binding
DNA binding
DNA helicase activity
chromatin binding
ATP-dependent DNA helicase activity
helicase activity
exonuclease activity
protein binding
ATP binding
3'-5' exonuclease activity
four-way junction helicase activity
ATPase activity
manganese ion binding
protein complex binding
protein homodimerization activity
3'-5' DNA helicase activity
ATP-dependent 3'-5' DNA helicase activity
G-quadruplex DNA binding
DNA helicase
telomere maintenance via recombination
telomere maintenance
DNA synthesis involved in DNA repair
strand displacement
replicative cell aging
DNA metabolic process
DNA replication
base-excision repair
double-strand break repair
cellular response to DNA damage stimulus
response to oxidative stress
brain development
aging
cell aging
cellular response to starvation
response to UV-C
multicellular organism aging
protein sumoylation
replication fork processing
nucleolus to nucleoplasm transport
DNA duplex unwinding
regulation of growth rate
regulation of apoptotic process
positive regulation of hydrolase activity
cellular response to gamma radiation
nucleic acid phosphodiester bond hydrolysis
regulation of signal transduction by p53 class mediator
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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