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Proteintech
WRNIP1 Polyclonal Antibody
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Product Details
16238-1-AP
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
WRNIP1 Fusion Protein Ag9040 (293-640 aa encoded by BC018923)
Conjugate
Form
Liquid
Concentration
0.38 mg/mL
Amount
57 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: VTLSATNAK TNDVRDVIKQ AQNEKSFFKR KTILFIDEIH RFNKSQQVNA ALLSRCRVIV LEKLPVEAMV TILMRAINSL GIHVLDSSRP TDPLSHSSNS SSEPAMFIED KAVDTLAYLS DGDARAGLNG LQLAVLARLS SRKMFCKKSG QSYSPSRVLI TENDVKEGLQ RSHILYDRAG EEHYNCISAL HKSMRGSDQN ASLYWLARML EGGEDPLYVA RRLVRFASED IGLADPSALT QAVAAYQGCH FIGMPECEVL LAQCVVYFAR APKSIEVYSA YNNVKACLRN HQGPLPPVPL HLRNAPTRLM KDLGYGKGYK YNPMYSEPVD QEYLPEELRG VDFFKQRRC (293-640 aa encoded by BC018923)
Target Information
Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATPase WRNIP1; FLJ22526; putative helicase RUVBL; RP11-420G6.2; unnamed protein product; Werner helicasae interacting protein 1; Werner helicase interacting protein 1; Werner helicase-interacting protein 1; Werner syndrome homolog interacting protein; wrnip1; wrnip1 {ECO:0000250|UniProtKB:Q96S55}
Gene Aliases: 4833444L21Rik; bA420G6.2; CFAP93; FAP93; WHIP; Wrnip; WRNIP1
UniProt ID: (Human) Q96S55, (Rat) Q8CG07, (Mouse) Q91XU0
Entrez Gene ID: (Human) 56897, (Rat) 282835, (Mouse) 78903
nucleotide binding
DNA binding
protein binding
ATP binding
enzyme activator activity
zinc ion binding
hydrolase activity
ATPase activity
single-stranded DNA-dependent ATP-dependent DNA helicase activity
identical protein binding
metal ion binding
DNA metabolism protein
DNA helicase
nucleic acid metabolism protein
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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