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Proteintech
WSB1 Polyclonal Antibody
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Product Details
11666-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
WSB1 Fusion Protein Ag2211 (1-280 aa encoded by BC021110)
Conjugate
Form
Liquid
Concentration
0.37 mg/mL
Amount
55.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MASFPPRVN EKEIVRLRTI GELLAPAAPF DKKCGRENWT VAFAPDGSYF AWSQGHRTVK LVPWSQCLQN FLLHGTKNVT NSSSLRLPRQ NSDGGQKNKP REHIIDCGDI VWSLAFGSSV PEKQSRCVNI EWHRFRFGQD QLLLATGLNN GRIKIWDVYT GKLLLNLVDH TEVVRDLTFA PDGSLILVSA SRDKTLRVWD LKDDGNMMKV LRGHQNWVYS CAFSPDSSML CSVGASKAVF LWNMDKYTMI RKLEGHHHDV VACDFSPDGA LLATASYDTR V (1-280 aa encoded by BC021110)
Target Information
WSB1 (WD repeat and SOCS box-containing 1), also known as SWIP1, is a 421 amino acid protein that contains one SOCS box domain and six WD repeats. Expressed as multiple alternatively spliced isoforms, WSB1 is thought to function as part of an SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as DIO2. Overexpression of WSB1 is implicated in pancreatic cancer progression, suggesting a role for WSB1 in carcinogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: SOCS box-containing WD protein SWiP-1; unnamed protein product; WD repeat and SOCS box-containing protein 1; WSB-1
Gene Aliases: SWIP1; WSB-1; WSB1
UniProt ID: (Human) Q9Y6I7
Entrez Gene ID: (Human) 26118
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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