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Invitrogen
WTAP Polyclonal Antibody
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Product Details
PA5-89988
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein (or fragment)
Conjugate
Form
Liquid
Concentration
0.47 mg/mL
Amount
47 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: DEEVEGMQST ILVLQQQLKE TRQQLAQYQQ QQSQASAPST SRTTASEPVE QSEATSKDCS RLTNGPSNGS SSRQRTSGSG FHREGNTTED DFPSSPGNGN KSSNSSEERT GRGGSGYVNQ LSAGYESVDS PTGSENSLTH QSND
Positive Samples: Rat spleen; Cellular Location: Nucleus, Nucleus speckle, nucleoplasm
Target Information
Wilms' tumor (WT) is an embryonal malignancy of the kidney that affects 1 in 10,000 infants and is observed in both sporadic and inherited forms. The Wilms' tumor protein (WT1) binds the DNA sequence GCGGGGGCG, a recognition element common to the early growth response (Egr) family of Zn2+ finger transcriptional activators, and functions as a transcriptional repressor. WTAP (Wilms tumor 1-associating protein) is a ubiquitously expressed nuclear protein that interacts with WT1 and may be involved in regulating mRNA splicing. WTAP is found in nuclear speckles, where it regulates the G2/M cell cycle transition by binding to the 3' UTR of cyclin A2, thus enhancing its stability. Additionally, WTAP inhibits expression of WT1 target genes and is able to impair the ability of WT1 to bind DNA. Two isoforms of WTAP exist due to alternative splicing events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Female-lethal(2)D homolog; FL(2)D; hFL(2)D; KIAA0105; NB4 apoptosis/differentiation related protein; PNAS-132; Pre-mRNA-splicing regulator WTAP; putative pre-mRNA splicing regulator female-lethal(2D); unnamed protein product; Wilms tumor 1 associated protein; Wilms tumor 1-associating protein; Wilms' tumour 1-associating protein; WT1-associated protein
Gene Aliases: 2810408K05Rik; 9430038B09Rik; KIAA0105; Mum2; RGD1563824; WTAP
UniProt ID: (Human) Q15007, (Mouse) Q9ER69
Entrez Gene ID: (Human) 9589, (Rat) 499020, (Mouse) 60532
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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