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Product Details
PA5-48292
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Not Applicable
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 243-271 amino acids of human WTIP.
Conjugate
Unconjugated
Form
Liquid
Concentration
0.26 mg/mL
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS
Contains
0.09% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
RRID
AB_2633750
Product Specific Information
Predicted to react with mouse based on sequence homology.
Target Information
Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates Hippo signaling pathway and antagonizes phosphorylation of YAP1. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. In podocytes, may play a role in the regulation of actin dynamics and/or foot process cytoarchitecture. In the course of podocyte injury, shuttles into the nucleus and acts as a transcription regulator that represses WT1-dependent transcription regulation, thereby translating changes in slit diaphragm structure into altered gene expression and a less differentiated phenotype. Involved in the organization of the basal body. Involved in cilia growth and positioning. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Wilms tumor protein 1-interacting protein; WT1-interacting protein
Gene Aliases: WTIP
UniProt ID: (Human) A6NIX2
Entrez Gene ID: (Human) 126374
Molecular Function:
transcription cofactor
response to hypoxia
transcription, DNA-templated
regulation of transcription, DNA-templated
cytoskeleton organization
regulation of cell morphogenesis
gene silencing by miRNA
negative regulation of hippo signaling
negative regulation of nucleic acid-templated transcription
positive regulation of gene silencing by miRNA
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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