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Fabgennix
WWOX3 Polyclonal Antibody, FITC
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Product Details
WWOX3-FITC
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide taken within amino acid region 250-300 on human WWOXdelta5-8 protein.
Conjugate
Excitation/Emission Max
498/517 nm
View spectra
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, store in dark
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development. May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Fragile site FRA16D oxidoreductase; Mutations: 150:OK; Short chain dehydrogenase/reductase family 41C member 1; unnamed protein product; WW domain-containing oxidoreductase; WW domain-containing protein WWOX; WWOX; WWOX v8
Gene Aliases: D16S432E; DEE28; EIEE28; FOR; FRA16D; HHCMA56; PRO0128; SCAR12; SDR41C1; WOX1; WWOX
UniProt ID: (Human) Q9NZC7
Entrez Gene ID: (Human) 51741, (Rat) 292041
osteoblast differentiation
apoptotic process
regulation of signal transduction
Wnt signaling pathway
negative regulation of Wnt signaling pathway
positive regulation of transcription from RNA polymerase II promoter
skeletal system morphogenesis
cellular response to transforming growth factor beta stimulus
intrinsic apoptotic signaling pathway by p53 class mediator
extrinsic apoptotic signaling pathway
positive regulation of extrinsic apoptotic signaling pathway
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
biological_process
oxidation-reduction process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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