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SH21A (SH2 DOMAIN-CONTAINING PROTEIN 1A)/(SAP) Polyclonal Antibody
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Product Details
X1490P
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Full-length recombinant SAP protein
Conjugate
Form
Liquid
Concentration
0.5-2 mg/mL
Amount
100 µg
Purification
Ammonium sulfate precipitation
Storage buffer
PBS
Contains
0.08% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Positive control: NK-92 cell lysate.
Target Information
This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Duncan disease SH2-protein; Duncan's disease; FLJ18687; FLJ92177; HGNC:10820; RP5-1052M9.3; SAP; SH2 domain-containing protein 1A; SH2D1A; signaling lymphocyte activation molecule-associated protein; Signaling lymphocytic activation molecule-associated protein; SLAM associated protein/SH2 domain protein 1A; SLAM-associated protein; T cell signal transduction molecule SAP; T-cell signal transduction molecule SAP; unnamed protein product
Gene Aliases: DSHP; EBVS; IMD5; LYP; MTCP1; SAP; SAP/SH2D1A; SH2D1A; XLP; XLPD; XLPD1
UniProt ID: (Human) O60880
Entrez Gene ID: (Human) 4068
adaptive immune response
immune system process
humoral immune response
cellular defense response
cell-cell signaling
natural killer cell activation
natural killer cell mediated cytotoxicity
innate immune response
positive regulation of natural killer cell mediated cytotoxicity
regulation of immune response
negative regulation of T cell receptor signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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