Invitrogen

XCL1/XCL2 Polyclonal Antibody

View all (2) XCL1/XCL2 antibodies

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XCL1/XCL2 Antibody in Western Blot (WB) — Western blot analysis of XCL1/XCL2 in K562 cell lysate. Samples were incubated with XCL1/XCL2 polyclonal antibody (Product # PA5-99826).

XCL1/XCL2 Antibody in Western Blot (WB) — Western blot analysis of XCL1/XCL2 in mouse lung. Samples were incubated with XCL1/XCL2 polyclonal antibody (Product # PA5-99826).

Product Details

PA5-99826

Applications	Tested Dilution	Publications
Western Blot (WB)	1:1,000-1:3,000	-

Product Specifications
Species Reactivity	Human, Mouse
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	A synthesized peptide derived from human XCL1/2, corresponding to a region within the internal amino acids.
Conjugate	Unconjugated
Form	Liquid
Concentration	1 mg/mL
Purification	Affinity chromatography
Storage buffer	PBS, pH 7.4, with 50% glycerol, 150mM NaCl
Contains	0.02% sodium azide
Storage conditions	-20°C
RRID	AB_2818759

Target Information

Lymphotactin, otherwise known as XCL1, is a member of the C-chemokine family that uniquely acts as a chemoattractant for lymphocytes, but not monocytes or neutrophils, suggesting an important regulatory role in lymphocyte trafficking and inflammation. Lymphotactin, shown to signal through chemokine XC receptor 1 (XCR1), is detected at the highest level in the spleen and at low levels in the lungs, small intestine and colon, and is abundantly and selectively expressed by activated T cells, in particular CD8+ T cells, and is also produced by NK cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ATAC; C motif chemokine 1; C motif chemokine 2; chemokine (C motif) ligand 1; chemokine (C motif) ligand 2; Cytokine SCM-1; Cytokine SCM-1 beta; Lymphotactin; Lymphotaxin; SCM-1-alpha; single cysteine motif 1a; small inducible cytokine subfamily C, member 1 (lymphotactin); small inducible cytokine subfamily C, member 2; Small-inducible cytokine C1; XC chemokine ligand 1; XC chemokine ligand 2

Gene Aliases: AI661682; ATAC; LPTN; LTN; SCM-1; SCM-1a; SCM-1b; SCM1; SCM1A; SCM1B; SCYC1; SCYC2; XCL1; XCL2

UniProt ID: (Human) P47992, (Human) Q9UBD3, (Mouse) P47993

Entrez Gene ID: (Human) 6375, (Human) 6846, (Mouse) 16963

Molecular Function: cytokine intercellular signal molecule

positive regulation of T cell mediated cytotoxicity monocyte chemotaxis positive regulation of leukocyte chemotaxis negative regulation of T cell cytokine production positive regulation of T cell cytokine production negative regulation of T-helper 1 type immune response signal transduction G-protein coupled receptor signaling pathway cell-cell signaling response to virus positive regulation of T cell chemotaxis neutrophil chemotaxis negative regulation of interferon-gamma production negative regulation of interleukin-2 production positive regulation of interleukin-10 production mature natural killer cell chemotaxis negative regulation of sequence-specific DNA binding transcription factor activity positive regulation of GTPase activity negative regulation of transcription, DNA-templated regulation of inflammatory response positive regulation of inflammatory response release of sequestered calcium ion into cytosol positive regulation of release of sequestered calcium ion into cytosol chemokine-mediated signaling pathway positive regulation of ERK1 and ERK2 cascade cellular response to interferon-gamma cellular response to interleukin-1 cellular response to interleukin-4 cellular response to tumor necrosis factor cellular response to transforming growth factor beta stimulus positive regulation of transforming growth factor beta production positive regulation of granzyme B production positive regulation of neutrophil chemotaxis positive regulation of thymocyte migration positive regulation of natural killer cell chemotaxis positive regulation of granzyme A production negative regulation of T-helper 1 cell activation positive regulation of B cell chemotaxis positive regulation of T-helper 2 cell cytokine production positive regulation of T-helper 1 cell cytokine production positive regulation of immunoglobulin production in mucosal tissue negative regulation of CD4-positive, alpha-beta T cell proliferation positive regulation of CD4-positive, alpha-beta T cell proliferation positive regulation of CD8-positive, alpha-beta T cell proliferation inflammatory response blood circulation lymphocyte chemotaxis positive regulation of immune response to tumor cell chemotaxis immune response positive regulation of innate immune response

Process(es)

chemokine activity chemokine receptor binding protein homodimerization activity CCR chemokine receptor binding protein binding cytokine activity