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|Tested species reactivity||Rat , Human , Mouse|
|Published species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide between amino acid 1-50 of the human XCT protein.|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Flow Cytometry (Flow)||2-3 µg/ml|
|Immunohistochemistry (Paraffin) (IHC (P))||5 µg/ml|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (IHC)||See 1 publications below|
This antibody is not recommended for Immunoprecipitation.
Permeablization is recommended prior to performing Flow analysis.
Suggested positive control: antigen standard for SLC7A11 (transient overexpression lysate), human stomach protein or stomach tissue lysate.
Mammalian amino acid transport systems consist of a large variety of transporters. The amino acid transporter, cystine/glutamic acid transporter xCT, for system xc has been proposed to be responsible for the cystine transport through the plasma membrane. System xc mediates an amino acid exchange and prefers cystine and glutamate as its substrates. The transporter designated as xCT requires 4F2 heavy chain (4F2hc:CD98) for its functional expression, and belongs to the family of amino acid transporters that associates with the type II membrane glycoproteins such as 4F2hc.
In brain, it has been proposed that system xc is up-regulated in glial cells upon oxidative stress and plays an essential roles to protect neurons against oxidative stress. Recent studies have implicated xCT as a gateway that Kaposi's sarcoma herpesvirus (KSHV) uses to enter cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Reduced expression of miRNA-27a modulates cisplatin resistance in bladder cancer by targeting the cystine/glutamate exchanger SLC7A11.
PA1-16893 was used in immunohistochemistry to study the role of SLC7A11 in the mechanism by which miRNA-27a expression levels modulate bladder cancer cisplatin resistance
|Drayton RM,Dudziec E,Peter S,Bertz S,Hartmann A,Bryant HE,Catto JW||Clinical cancer research : an official journal of the American Association for Cancer Research (20:1990)||2014|
sut, 9930009M05Rik, CCBR1, AI451155, xCT
amino acid transport system xc-, cysteine/glutamate transporter, cystine/glutamate transporter, sodium independent anionic amino acid transport system, solute carrier family 7 member 11, solute carrier family 7 (cationic amino acid transporter, y+ system), member 11, calcium channel blocker resistance protein CCBR1, solute carrier family 7, (cationic amino acid transporter, y+ system) member 11, Cysteine/glutamate transporter antibody, Amino acid transport system xc-xCT antibody, Calcium channel blocker resistance protein CCBR1 antibody.