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Positive Control: Hela cell lysate, A431 cell lysate, rat large intestine tissue, human thyroid tissue, human colon carcinoma tissue, human skin tissue, human prostate carcinoma tissue, human breast tissue, human breast carcinoma tissue, human stomach carcinoma tissue, human small intestine tissue, mouse testis tissue, mouse kidney tissue.
Subcellular Location: Nucleus.
The XPA (xeroderma pigmentosumgroup A) protein specifically recognizes the UV-orchemically damaged DNA lesions, and triggers thenucleotide excision repair process. XPA binds to thereplication protein A (RPA) or the excision repaircross complementing 1 protein (ERCC 1). In the absence of nucleotide excision repair persisting (unrepaired) DNA lesions (adducts) may lead to the accumulation of gene mutations and ultimately to cancer. Xeroderma pigmentosum patients have a >2000 fold increased risk to develop skin cancer atsun-exposed areas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DNA repair protein complementing XP-A cells; DNA repair protein complementing XP-A cells homolog; excision repair-controlling; mutant xeroderma pigmentosum complementation group A; Xeroderma pigmentosum group A-complementing protein; Xeroderma pigmentosum group A-complementing protein homolog; xeroderma pigmentosum, complementation group A
Gene Aliases: AI573865; XP1; XPA; XPAC
UniProt ID: (Human) P23025, (Mouse) Q64267
Entrez Gene ID: (Human) 7507, (Mouse) 22590, (Rat) 298074
Molecular Function:
damaged DNA-binding protein
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