Bioss

XPB Polyclonal Antibody

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Datasheet
Protocols
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Datasheet
Protocols
Questions & Answers
Tech Support
XPB Polyclonal Antibody

Product Details

BS-4260R

Applications
Tested Dilution
Publications

Western Blot (WB)

Assay-dependent
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human XPB/ERCC3, amino acids 601-700.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

The human XPB DNA helicase is a subunit of the DNA repair/basal transcription factor TFIIH, and is involved in early steps of the nucleotide excision repair (NER) pathway. Two distinct clinical phenotypes, xeroderma pigmentosum associated with Cockayne's syndrome (XP/CS) and trichothiodystrophy (TTD), can be due to mutations in the XPB gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Basic transcription factor 2 89 kDa subunit; BTF2 p89; BTF2-p89; DNA 3'-5' helicase/translocase XPB; DNA excision repair protein ERCC-3; DNA repair helicase; DNA repair protein complementing XP-B cells; excision repair 3; excision repair cross-complementation group 3; excision repair cross-complementing rodent repair deficiency, complementation group 3; General transcription and DNA repair factor IIH helicase/translocase subunit XPB; TFIIH 89 kDa subunit; TFIIH basal transcription factor complex 89 kDa subunit; TFIIH basal transcription factor complex helicase XPB subunit; TFIIH p89; TFIIH subunit XPB; Xeroderma pigmentosum group B-complementing protein; xeroderma pigmentosum, complementation group B

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Gene Aliases: BTF2; BTF2 p89; Ercc-3; ERCC3; GTF2H; RAD25; TFIIH; TTD2; XPB; XPBC

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UniProt ID: (Human) P19447, (Mouse) P49135, (Rat) Q4G005

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Entrez Gene ID: (Human) 2071, (Mouse) 13872, (Rat) 291703

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Function(s)
DNA binding damaged DNA binding ATP-dependent DNA helicase activity helicase activity protein kinase activity protein binding ATP binding GTP binding protein C-terminus binding DNA-dependent ATPase activity transcription factor binding RNA polymerase II carboxy-terminal domain kinase activity ATPase activity dATP binding peptide binding 3'-5' DNA helicase activity protein N-terminus binding nucleotide binding hydrolase activity DNA metabolism protein DNA helicase nucleic acid metabolism protein
Process(es)
nucleotide-excision repair, DNA duplex unwinding response to hypoxia DNA topological change DNA repair transcription-coupled nucleotide-excision repair nucleotide-excision repair nucleotide-excision repair, preincision complex stabilization nucleotide-excision repair, preincision complex assembly nucleotide-excision repair, DNA incision, 3'-to lesion nucleotide-excision repair, DNA incision, 5'-to lesion transcription initiation from RNA polymerase I promoter transcription elongation from RNA polymerase I promoter termination of RNA polymerase I transcription transcription from RNA polymerase II promoter transcription initiation from RNA polymerase II promoter transcription elongation from RNA polymerase II promoter 7-methylguanosine mRNA capping protein phosphorylation apoptotic process response to oxidative stress protein localization response to UV UV protection viral process nucleotide-excision repair, DNA incision hair cell differentiation positive regulation of apoptotic process positive regulation of transcription from RNA polymerase II promoter embryonic organ development global genome nucleotide-excision repair regulation of mitotic cell cycle phase transition transcription, DNA-templated regulation of transcription, DNA-templated cellular response to DNA damage stimulus
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