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Bethyl Laboratories
XPC Polyclonal Antibody
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FIGURE: 1 / 1
XPC Antibody (A301-122A) in WB
Detection of human XPC by western blot and immunoprecipitation. Samples: Whole cell lysate (5, 15 and 50 µg for WB; 1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-XPC antibody (Product # A301-122A) used for WB at 0.04 µg/mL (A) and 0.1 µg/mL (B) and used for IP at 3 µg/mg lysate. XPC was also immunoprecipitated by rabbit anti-XPC antibody A301-121A, which recognizes an upstream epitope. Detection: Chemiluminescence with exposure times of 3 seconds (A) and 30 seconds (B).
Product Details
A301-122A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 890 and 940 of Human xeroderma pigmentosum, complementation group C.
Conjugate
Form
Liquid
Concentration
0.20 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.0 to 8.0, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Dog, Orangutan, Monkey, Gorilla and Chimpanzee
Target Information
This gene encodes a component of the nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway, including Xeroderma pigmentosum (XP) A-G and V, Cockayne syndrome (CS) A and B, and trichothiodystrophy (TTD) group A, etc. This component, XPC, plays an important role in the early steps of global genome NER, especially in damage recognition, open complex formation, and repair protein complex formation. Mutations in this gene or some other NER components result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DNA repair protein complementing XP-C cells; mutant xeroderma pigmentosum group C; NER; nucleotide excision repair protein; p125; unnamed protein product; Xeroderma pigmentosum group C-complementing protein; xeroderma pigmentosum, complementation group C
Gene Aliases: p125; RAD4; XP3; XPC; XPCC
UniProt ID: (Human) Q01831
Entrez Gene ID: (Human) 7508
pyrimidine dimer repair by nucleotide-excision repair
DNA repair
nucleotide-excision repair
mismatch repair
cellular response to DNA damage stimulus
regulation of mitotic cell cycle
response to xenobiotic stimulus
response to UV-B
response to auditory stimulus
intra-S DNA damage checkpoint
positive regulation of transcription, DNA-templated
UV-damage excision repair
regulation of cell cycle phase transition
regulation of mitotic cell cycle phase transition
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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