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OriGene
XPC Polyclonal Antibody
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Product Details
TA890217
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Full length human recombinant protein of human HSD17B13 produced in HEK293T cell.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS with 50% glycerol, 1% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This gene encodes a component of the nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway, including Xeroderma pigmentosum (XP) A-G and V, Cockayne syndrome (CS) A and B, and trichothiodystrophy (TTD) group A, etc. This component, XPC, plays an important role in the early steps of global genome NER, especially in damage recognition, open complex formation, and repair protein complex formation. Mutations in this gene or some other NER components result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DNA repair protein complementing XP-C cells; mutant xeroderma pigmentosum group C; NER; nucleotide excision repair protein; p125; unnamed protein product; Xeroderma pigmentosum group C-complementing protein; xeroderma pigmentosum, complementation group C
Gene Aliases: p125; RAD4; XP3; XPC; XPCC
UniProt ID: (Human) Q01831
Entrez Gene ID: (Human) 7508
pyrimidine dimer repair by nucleotide-excision repair
DNA repair
nucleotide-excision repair
mismatch repair
cellular response to DNA damage stimulus
regulation of mitotic cell cycle
response to xenobiotic stimulus
response to UV-B
response to auditory stimulus
intra-S DNA damage checkpoint
positive regulation of transcription, DNA-templated
UV-damage excision repair
regulation of cell cycle phase transition
regulation of mitotic cell cycle phase transition
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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