The DNA repair endonuclease Mus81 facilitates fast DNA replication in the absence of exogenous damage.
Fu H,Martin MM,Regairaz M,Huang L,You Y,Lin CM,Ryan M,Kim R,Shimura T,Pommier Y,Aladjem MI
MA5-12054 was used in western blot to study the role of Mus81 in DNA replication
Thu Apr 16 00:00:00 EDT 2015
Phase II study of cetuximab in combination with cisplatin and radiation in unresectable, locally advanced head and neck squamous cell carcinoma: Eastern cooperative oncology group trial E3303.
Clinical cancer research : an official journal of the American Association for Cancer Research
Egloff AM,Lee JW,Langer CJ,Quon H,Vaezi A,Grandis JR,Seethala RR,Wang L,Shin DM,Argiris A,Yang D,Mehra R,Ridge JA,Patel UA,Burtness BA,Forastiere AA
MA5-12054 was used in immunohistochemistry to characterize unresectable, locally advanced head and neck squamous cell carcinoma in an Easter cooperative oncology group trial E3303 phase II study of cetuximab in combination with radiation and cisplatin
Wed Oct 01 00:00:00 EDT 2014
Comparison of ERCC1/XPF genetic variation, mRNA and protein levels in women with advanced stage ovarian cancer treated with intraperitoneal platinum.
Deloia JA,Bhagwat NR,Darcy KM,Strange M,Tian C,Nuttall K,Krivak TC,Niedernhofer LJ
MA5-12054 was used in western blot to study potential correlations between ERCC1 and XPF expression, genotype and clinical outcome in advanced epithelial ovarian cancer patients undergoing platinum chemotherapy
Sat Sep 01 00:00:00 EDT 2012
Role of interaction of XPF with RPA in nucleotide excision repair.
Journal of molecular biology
Fisher LA,Bessho M,Wakasugi M,Matsunaga T,Bessho T
MA5-12054 was used in western blot to study the role of the interaction of RPA and XPF during nucleotide excision repair
Fri Oct 21 00:00:00 EDT 2011
The knock-down of ERCC1 but not of XPF causes multinucleation.
Rageul J,Frëmin C,Ezan F,Baffet G,Langouët S
MA5-12054 was used in immunocytochemistry to study the role of ERCC1 in cell cycle progression and multinucleation
Mon Sep 05 00:00:00 EDT 2011
Poly(ADP-ribose) polymerase and XPF-ERCC1 participate in distinct pathways for the repair of topoisomerase I-induced DNA damage in mammalian cells.
Nucleic acids research
Zhang YW,Regairaz M,Seiler JA,Agama KK,Doroshow JH,Pommier Y
MA5-12054 was used in western blot to investigate the diffrent role of PARP and XPF-ERCC1 in mammalian DNA repair
Sun May 01 00:00:00 EDT 2011
SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype.
Stoepker C,Hain K,Schuster B,Hilhorst-Hofstee Y,Rooimans MA,Steltenpool J,Oostra AB,Eirich K,Korthof ET,Nieuwint AW,Jaspers NG,Bettecken T,Joenje H,Schindler D,Rouse J,de Winter JP
MA5-12054 was used in immunoprecipitation and western blot to study a novel Fanconi anemia subtype in which SLX4 is mutated
Tue Feb 01 00:00:00 EST 2011
Mutations of the SLX4 gene in Fanconi anemia.
Kim Y,Lach FP,Desetty R,Hanenberg H,Auerbach AD,Smogorzewska A
MA5-12054 was used in immunoprecipitation to study SLX4 mutations in two patients with Fanconi anemia
Tue Feb 01 00:00:00 EST 2011
Downregulation of XPF-ERCC1 enhances cisplatin efficacy in cancer cells.
Arora S,Kothandapani A,Tillison K,Kalman-Maltese V,Patrick SM
MA5-12054 was used in western blot to study the effect of cisplatin on XPF-ERCC1 in cancer cells
Thu Jul 01 00:00:00 EDT 2010
Mislocalization of XPF-ERCC1 nuclease contributes to reduced DNA repair in XP-F patients.
Ahmad A,Enzlin JH,Bhagwat NR,Wijgers N,Raams A,Appledoorn E,Theil AF,J Hoeijmakers JH,Vermeulen W,J Jaspers NG,Schärer OD,Niedernhofer LJ
MA5-12054 was used in Western Blotting to determine how mutations in Xeroderma pigmentosum-F can lead to such diverse symptoms.
Fri Mar 05 00:00:00 EST 2010
Immunodetection of DNA repair endonuclease ERCC1-XPF in human tissue.
Bhagwat NR,Roginskaya VY,Acquafondata MB,Dhir R,Wood RD,Niedernhofer LJ
MA5-12054 was used in immunocytochemistry, immunoprecipitation, and western blot to evaluate a panel of antibodies for the immunodetection of DNA repair endonuclease ERCC1-XPF in human tissue
Tue Sep 01 00:00:00 EDT 2009
Human XPF controls TRF2 and telomere length maintenance through distinctive mechanisms.
Mechanisms of ageing and development
Wu Y,Mitchell TR,Zhu XD
MA5-12054 was used in immunoprecipitation to study the distinct mechanisms by which XPF-ERCC1 regulates TRF2 function and maintenance of telomere length
Wed Oct 01 00:00:00 EDT 2008
Processing of a psoralen DNA interstrand cross-link by XPF-ERCC1 complex in vitro.
The Journal of biological chemistry
Fisher LA,Bessho M,Bessho T
MA5-12054 was used in western blot to study the molecular mechanism by which the XPF-ERCC1 complex processes a DNA substarate containing a single psoralen interstrand cross-link
Fri Jan 18 00:00:00 EST 2008
Molecular characterization of spontaneous mesenchymal stem cell transformation.
Rubio D,Garcia S,Paz MF,De la Cueva T,Lopez-Fernandez LA,Lloyd AC,Garcia-Castro J,Bernad A
MA5-12054 was used in western blot to investigate the molecular mechanisms of spontaneous mesenchymal stem cell transformation
Wed Jan 02 00:00:00 EST 2008