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Invitrogen
XPF Monoclonal Antibody (219)
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Product Details
MA5-12054
Applications
Tested Dilution
Publications
Product Specifications
Published species
Hamster,
Human
Host/Isotype
Mouse
/ IgG2, kappa
Class
Monoclonal
Type
Antibody
Clone
219
Immunogen
Recombinant human XPF protein
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Amount
200 µg
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-12054 targets XPF in IHC (P) and WB applications and shows reactivity with Human samples.
The MA5-12054 immunogen is recombinant human XPF protein.
Target Information
The structure specific ERCC 1 / XPF endonuclease complex is implicated in the repair of two distinct types of lesions in DNA: NER for UV induced lesions and bulky chemical adducts; and recombination repair of the very genotoxic interstrand cross links. NER mechanism involves dual incisions on both sides of the damage catalyzed by two nucleases. In mammalian cells, XPG cleaves 3' of the DNA lesion while the ERCC1 / XPF complex makes the 5' incision. ERCC1 / XPF probably plays a role in processing partially processed recombination intermediates.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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