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Invitrogen
XPG Polyclonal Antibody
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Product Details
PA5-76039
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant full length Human XPG.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
Xeroderma pigmentosum type G (XPG) is a human genetic disease exhibiting extreme sensitivity to sunlight. The XPG protein, a member of the flap endonuclease 1 (FEN-1) structure-specific DNA repair endonuclease family, is an enzyme essential for DNA repair of the major kinds of solar ultraviolet (UV)-induced DNA damages. Human XPG nuclease makes the 3' incision during nucleotide excision repair of DNA. The enzyme cleaves model DNA bubble structures specifically near the junction of unpaired DNA with a duplex region. A 29-amino acid region of human XPG (residues 981-1009) contains the PCNA binding activity. A conserved arginine in XPG (Arg992) is crucial for its PCNA binding activity. Replication Protein A (RPA) binds specifically and directly to two excision repair proteins, the xeroderma pigmentosum damage-recognition protein XPA and the endonuclease XPG.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: COFS 3; DNA excision repair protein ERCC-5; DNA repair protein complementing XP-G cells; DNA repair protein complementing XP-G cells homolog; ERCC 5; ERCC5; ERCC5-201; ERCM 2; excision repair cross-complementation group 5; excision repair cross-complementing rodent repair deficiency, complementation group 5; OTTHUMP00000064902; RP11-484I6.5; unnamed protein product; Xe; xeroderma pigmentosum; Xeroderma pigmentosum group G-complementing protein; xeroderma pigmentosum group G-complementing protein homolog; xeroderma pigmentosum, complementation group G; XPG; XPG-complementing protein
Gene Aliases: COFS3; ERCC5; ERCC5-201; ERCM2; UVDR; XPG; XPGC
UniProt ID: (Human) P28715
Entrez Gene ID: (Human) 2073, (Mouse) 22592, (Rat) 301382
bubble DNA binding
RNA polymerase II core binding
DNA binding
damaged DNA binding
double-stranded DNA binding
single-stranded DNA binding
catalytic activity
nuclease activity
endonuclease activity
endodeoxyribonuclease activity
protein binding
enzyme activator activity
hydrolase activity
hydrolase activity, acting on ester bonds
protein homodimerization activity
macromolecular complex binding
metal ion binding
phosphoric ester hydrolase activity
T/G mismatch-specific endonuclease activity
retroviral 3' processing activity
protein N-terminus binding
molecular_function
DNA metabolism protein
double-strand break repair via homologous recombination
DNA repair
transcription-coupled nucleotide-excision repair
base-excision repair, AP site formation
nucleotide-excision repair
DNA recombination
cellular response to DNA damage stimulus
response to UV
response to UV-C
negative regulation of apoptotic process
nucleotide-excision repair, DNA incision, 3'-to lesion
determination of adult lifespan
UV protection
multicellular organism growth
DNA catabolic process, endonucleolytic
biological_process
metabolic process
nucleic acid phosphodiester bond hydrolysis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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